CAJ | 학술논문

目的：近年有许多关于同型半胱氨酸（Hcy）与左心室射血分数（LVEF）相关性的研究。但在2型糖尿病患者中，两者关系仍不清楚。本研究将评估2型糖尿病患者Hcy与LVEF的相关性。方法选择2型糖尿病患者72例，按是否合并冠心病分为两组，均检测血Hcy、糖化血红蛋白、甘油三酯（TG）、总胆固醇（TC）等水平。心脏超声评估LVEF。结果两组患者收缩压、舒张压、糖化血红蛋白、TC及TG比较均无统计学意义（P＞0.05）；糖尿病合并冠心病组Hcy明显高于单纯糖尿病组，差异具有统计学意义（P ＜0.05）；Hcy是糖尿病合并冠心病组LVEF＜55％的危险因素[OR＝1.211（95%CI 1.041~1.408）]；糖尿病合并冠心病组患者血 Hcy 水平与LVEF 明显负相关（r=-0.706，P=0.000）。结论2型糖尿病患者血清Hcy与LVEF呈负相关，Hcy是2型糖尿病合并冠心病患者LVEF＜55％的危险因素。
목적：근년유허다관우동형반광안산（Hcy）여좌심실사혈분수（LVEF）상관성적연구。단재2형당뇨병환자중，량자관계잉불청초。본연구장평고2형당뇨병환자Hcy여LVEF적상관성。방법선택2형당뇨병환자72례，안시부합병관심병분위량조，균검측혈Hcy、당화혈홍단백、감유삼지（TG）、총담고순（TC）등수평。심장초성평고LVEF。결과량조환자수축압、서장압、당화혈홍단백、TC급TG비교균무통계학의의（P＞0.05）；당뇨병합병관심병조Hcy명현고우단순당뇨병조，차이구유통계학의의（P ＜0.05）；Hcy시당뇨병합병관심병조LVEF＜55％적위험인소[OR＝1.211（95%CI 1.041~1.408）]；당뇨병합병관심병조환자혈 Hcy 수평여LVEF 명현부상관（r=-0.706，P=0.000）。결론2형당뇨병환자혈청Hcy여LVEF정부상관，Hcy시2형당뇨병합병관심병환자LVEF＜55％적위험인소。
Objective A link between homocysteine (Hcy) and left ventricular ejection fraction(LVEF) emerged from re-cent studies but was yet not explored specifically in type 2 diabetic patients. This study aimed to assess the relationship between LVEF and Hcy in type 2 diabetic patients. Methods A total of 72 type 2 diabetic patients were selected for this study and were divided into two groups (40 examples with coronary heart disease, 32 examples without coronary heart disease) javascript:Serum Hcy,glycosylated hemoglobin,cholesterol(TC) and triglyceride(TG) were analyzed.LVEF was assessed by echocardiography. Results There was no difference in systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin,total cholesterol and triglyceride in two groups of patients (P>0.05);The serum Hcy was obvi-ously higher in type 2 diabetic patients with coronary heart disease compared to those without (P<0.05);Factors signifi-cantly associated with a LVEF<55%were serum Hcy OR=1.211(95%CI 1.041~1.408) in type 2 diabetic patients with coronary heart disease.The serum Hcy had significant negatively correlation with LVEF (r=-0.706,P=0.000) in type 2 diabetic patients with coronary heart disease. Conclusion This study highlights an inverse relationship between Hcy and LVEF in type 2 diabetic patients with coronary artery disease.The serum Hcy is a risk factor associated with a LVEF<55%.