CAJ | 학술논문

目的：了解雄激素受体（AR）在雄性激素源性脱发（AGA）患者顶部表皮、毛囊、皮脂腺、汗腺中的表达情况。方法：选取26例雄性激素源性脱发患者顶部、枕部以及10例非脱发者的顶部头皮标本，用免疫组织化学检测表皮、毛囊、皮脂腺、汗腺中AR的表达。结果：脱发患者头顶部毛囊、皮脂腺、汗腺AR表达均明显强于枕部和非脱发者枕部，差异均有统计学意义（P<0.05）；脱发患者枕部毛囊、皮脂腺、汗腺AR表达与非脱发者顶部AR表达比较差异均无统计学意义（P>0.05）；所有标本表皮中AR均为阴性。结论：AR在AGA患者头顶部毛囊、皮脂腺、汗腺的高表达，可能是AGA重要原因之一。
목적：료해웅격소수체（AR）재웅성격소원성탈발（AGA）환자정부표피、모낭、피지선、한선중적표체정황。방법：선취26례웅성격소원성탈발환자정부、침부이급10례비탈발자적정부두피표본，용면역조직화학검측표피、모낭、피지선、한선중AR적표체。결과：탈발환자두정부모낭、피지선、한선AR표체균명현강우침부화비탈발자침부，차이균유통계학의의（P<0.05）；탈발환자침부모낭、피지선、한선AR표체여비탈발자정부AR표체비교차이균무통계학의의（P>0.05）；소유표본표피중AR균위음성。결론：AR재AGA환자두정부모낭、피지선、한선적고표체，가능시AGA중요원인지일。
To investigate AR expression in the top of epidermis,hair follicle and sebaceous gland, sudoriferous gland.Method:The top and the occipital scalp of AGA patients(n=26)and the top scalp of non-alopecia people(n=10)as specimens were obtained,and AR expressions in the epidermis,hair follicle and sebaceous gland, sudoriferous gland were studied by immunohistochemistry method.Result:AR expressions of hair follicle,sebaceous gland,sudoriferous gland on the top of AGA patients were stronger than the occipital of AGA patients and the top of non-alopecia(P<0.05);AR expressions of hair follicle,sebaceous gland,sudoriferous gland in the occipital of AGA patients had no significant difference with the top of non-alopecia(P>0.05). All samples were negative for AR in epidermis. Conclusion:AR expressions on the top of hair follicle and sebaceous gland,sudoriferous gland in AGA patients may be one of the key factors leading to AGA.