CAJ | 학술논문

目的：对慢性阻塞性肺病患者血浆C反应蛋白及D-二聚体的变化进行研究。方法：选取2012年1月-2013年12月本院收治的89例慢性阻塞性肺疾病患者，其中稳定期患者43例（COPD组），急性加重期患者46例（AECOPD组），选取同期44例健康体检者作为对照组。对所有患者均采集静脉血进行C反应蛋白及D-二聚体的检测，观察比较三组的观察指标含量及阳性率。结果：与健康对照组比较，COPD组、AECOPD组的血浆C反应蛋白及D-二聚体含量均明显增高，且AECOPD组更为显著，而治疗后明显低于治疗前，差异均有统计学意义（P<0.05）。COPD组、AECOPD组的血浆C反应蛋白及D-二聚体的检测阳性率均明显高于健康对照组，AECOPD组明显高于COPD组，差异均有统计学意义（P<0.05）。结论：C反应蛋白及D-二聚体联合检测对COPD患者的早期诊断、治疗、病情评估及预后观察具有重要的临床价值。
목적：대만성조새성폐병환자혈장C반응단백급D-이취체적변화진행연구。방법：선취2012년1월-2013년12월본원수치적89례만성조새성폐질병환자，기중은정기환자43례（COPD조），급성가중기환자46례（AECOPD조），선취동기44례건강체검자작위대조조。대소유환자균채집정맥혈진행C반응단백급D-이취체적검측，관찰비교삼조적관찰지표함량급양성솔。결과：여건강대조조비교，COPD조、AECOPD조적혈장C반응단백급D-이취체함량균명현증고，차AECOPD조경위현저，이치료후명현저우치료전，차이균유통계학의의（P<0.05）。COPD조、AECOPD조적혈장C반응단백급D-이취체적검측양성솔균명현고우건강대조조，AECOPD조명현고우COPD조，차이균유통계학의의（P<0.05）。결론：C반응단백급D-이취체연합검측대COPD환자적조기진단、치료、병정평고급예후관찰구유중요적림상개치。
To study the change of plasma C-reactive protein and D-dimer in patients with chronic obstructive pulmonary disease.Method:89 patients with chronic obstructive pulmonary disease from January 2012 to December 2013 in our hospital were selected,including 43 stable patients(the COPD group),46 patients with acute exacerbation(the AECOPD group).44 healthy people during the same period were selected as the control group. All patients were conducted C-reactive protein and D-dimer blood collection and testing,content and positive rate of indicators in the three groups were observed and compared.Result:Compared with the healthy control group,the plasma C-reactive protein and D-dimer levels in COPD group and AECOPD group were significantly higher,AECOPD group was more significant,but after treatment,it was significantly lower than before treatment,the differences were statistically significant(P<0.05).The plasma C-reactive protein and D-dimer testing positive rate in COPD group and AECOPD group were significantly higher than the healthy control group,AECOPD group was significantly higher than the COPD group,the differences were statistically significant(P<0.05).Conclusion:C-reactive protein and D-dimer have important clinical value in the early diagnosis,treatment,evaluation and prognosis of patients with COPD.