CAJ | 학술논문

　　目的：在大鼠5/6肾切除模型上探讨心脏成纤维细胞生长因子－2（FGF-2）表达情况及 NADPH 氧化酶对FGF-2表达的影响。方法：构建5/6肾切除动物模型并给予NADPH 氧化酶抑制剂apocynin 干预8周，观察大鼠心肌组织FGF-2的表达情况。结果：apocynin 改善5/6肾切除术导致的大鼠血压升高、体重下降及血肌酐的蓄积，并抑制5/6肾切除术导致心脏FGF-2表达。结论：NADPH 氧化酶是调控慢性肾脏病（CKD）时心脏FGF-2的合成因素之一。
　　목적：재대서5/6신절제모형상탐토심장성섬유세포생장인자－2（FGF-2）표체정황급 NADPH 양화매대FGF-2표체적영향。방법：구건5/6신절제동물모형병급여NADPH 양화매억제제apocynin 간예8주，관찰대서심기조직FGF-2적표체정황。결과：apocynin 개선5/6신절제술도치적대서혈압승고、체중하강급혈기항적축적，병억제5/6신절제술도치심장FGF-2표체。결론：NADPH 양화매시조공만성신장병（CKD）시심장FGF-2적합성인소지일。
Objective: To investigate the effects of NADPH oxidase on the expression of fibroblast growth factor-2 (FGF-2) in chronic kidney disease (CKD). Method: CKD models were established in male Sprague-Dawley rats and treated with apocynin for 8 weeks. Results: NADPH oxidase inhibition ameliorated 5/6 nephrectomy induced hypertension, weight loss and creatinine accumulation. Furthermore, apocynin treatment reduced the expression of cardiac FGF-2 in 5/6 nephrectomized rats. Conclusions: The study demonstrated that NADPH oxidase plays a pivotal role in regulating the expression of FGF-2 in CKD.