CAJ | 학술논문

　　目的：研究和比较纳美芬和纳洛酮治疗急性酒精中毒的疗效。方法：将2010年4月2012年3月彭湃纪念医院急诊科就诊的急性酒精中毒患者196例随机分为研究组和对照组，兴奋期36例中纳入研究组17例，对照组19例，共济失调期121例中纳入研究组61例，对照组60例，昏睡昏迷期39例中纳入研究组19例，对照组20例，每组根据病情等级的不同给予不同剂量的纳美芬或纳洛酮治疗，比较两组治疗120 min 后的疗效。结果：两组治疗兴奋期酒精中毒的疗效无显著性差异（P＞0．05），研究组治疗共济失调期和昏睡昏迷期酒精中毒的疗效优于对照组（P 均＜0．05）。结论：纳美芬治疗共济失调期和昏睡昏迷期急性酒精中毒的疗效优于纳洛酮。
　　목적：연구화비교납미분화납락동치료급성주정중독적료효。방법：장2010년4월2012년3월팽배기념의원급진과취진적급성주정중독환자196례수궤분위연구조화대조조，흥강기36례중납입연구조17례，대조조19례，공제실조기121례중납입연구조61례，대조조60례，혼수혼미기39례중납입연구조19례，대조조20례，매조근거병정등급적불동급여불동제량적납미분혹납락동치료，비교량조치료120 min 후적료효。결과：량조치료흥강기주정중독적료효무현저성차이（P＞0．05），연구조치료공제실조기화혼수혼미기주정중독적료효우우대조조（P 균＜0．05）。결론：납미분치료공제실조기화혼수혼미기급성주정중독적료효우우납락동。
Objective:To research and compare the therapeutic effects of Nalmefene and Naloxone for patients with acute alcoholism..Methods:196 patients with acute alcoholism in the department of emergency of Pengbai memorial hospital from Apr 2010 to Mar 2012 were randomly divided into the research group and control group. There were 36 cases in excitement stage (17 in research group and 19 in control group), 121 cases in ataxia stage (61 in research group and 60 in control group) and 39 cases in comatose stage (19 in research group and 20 in control group). The cases were accepted different doses of Nalmefene or Naloxone according to the clinical situations. The therapeutic effects were compared between the two groups after the treatment were begun 120 minutes. Results:The therapeutic effects were no significantly different for patients with acute alcoholism in excitement stage between the two groups, while the therapeutic effects for patients with acute alcoholism in ataxia stage or comatose stage were significantly higher in the research group than those in the control group, both P<0.05. Conclusion:Nalmefene is superior to Naloxone in treating patient with acute alcoholism in ataxia stage or comatose stage.