CAJ | 학술논문

　　目的：探讨急性冠脉综合症（ACS）患者死亡率与内皮细胞激活因子的相关性。方法：检测未接受冠状动脉介入治疗的339例 ACS 患者血浆中的血浆血管性血友病因子（VWF）、血浆血管性血友病因子前肽（VWF：pp）和骨保护素（OPG），观察其与住院期间死亡的关系。结果：住院期间死亡（死亡组）46例，存活（存活组）293例。死亡组VWF：pp 明显高于生存患者组（P＜0．05）；高浓度 OPG 者的死亡率明显高于低浓度 OPG 者（P＜0．05）。结论：未接受冠状动脉介入治疗的 ACS 患者中，内皮细胞功能的激活和紊乱与住院期间死亡率相关。
　　목적：탐토급성관맥종합증（ACS）환자사망솔여내피세포격활인자적상관성。방법：검측미접수관상동맥개입치료적339례 ACS 환자혈장중적혈장혈관성혈우병인자（VWF）、혈장혈관성혈우병인자전태（VWF：pp）화골보호소（OPG），관찰기여주원기간사망적관계。결과：주원기간사망（사망조）46례，존활（존활조）293례。사망조VWF：pp 명현고우생존환자조（P＜0．05）；고농도 OPG 자적사망솔명현고우저농도 OPG 자（P＜0．05）。결론：미접수관상동맥개입치료적 ACS 환자중，내피세포공능적격활화문란여주원기간사망솔상관。
Objective:To investigate the relationship between endothelial cell activation markers and mortality in patients with acute coronary syndrome (ACS). Methods: Plasma levels of endothelial cell activation markers such as von Willebrand factor(VWF), von Willebrand factor propeptide(VWF:pp) and osteoprotegerin (OPG) were measured of 339 patients with ACS who underwent expectant treatment. The relationship between the endothelial cell activation markers and the mortality were observed during the in-hospital periods. Results: There were 46 deaths (death group) and 293 survivors (survival group) during the in-hospital periods. Median values of VWF and VWF:pp were significantly higher in the death group than those in the survival group (both P<0.05). The mortality was significantly higher in patients with high OPG than that in patients with low OPG (P<0.05). Conclusion: In patients with ACS undergoing expectant treatment, increased endothelial cell activation and dysfunction is associated with mortality during the in-hospital periods.