CAJ | 학술논문

　　目的：阐明中药方剂的化学成分作用机理及其与治疗目标之间的关系，从多种成分中发现有效成分群性。方法：以中药方剂及其治疗的某一疾病为研究对象，以实体语法系统为理论框架，构建中药方剂有效成分群辨识的实体语法系统，推断其化学成分对疾病的作用，并以此确定治疗该疾病的有效成分群。结果：本文从治疗玉型糖尿病的方剂“白虎汤合消渴方”中识别出16个作用于玉型糖尿病网络中12个蛋白的化学成分，其中9个化学成分对玉型糖尿病的治疗具有积极的作用，可作为有效成分群的候选对象。结论：本法能够用于辨识中药方剂的有效成分群，揭示中药方剂的分子作用机制，并为中药方剂的有效成分研究提供一条新途径。
　　목적：천명중약방제적화학성분작용궤리급기여치료목표지간적관계，종다충성분중발현유효성분군성。방법：이중약방제급기치료적모일질병위연구대상，이실체어법계통위이론광가，구건중약방제유효성분군변식적실체어법계통，추단기화학성분대질병적작용，병이차학정치료해질병적유효성분군。결과：본문종치료옥형당뇨병적방제“백호탕합소갈방”중식별출16개작용우옥형당뇨병망락중12개단백적화학성분，기중9개화학성분대옥형당뇨병적치료구유적겁적작용，가작위유효성분군적후선대상。결론：본법능구용우변식중약방제적유효성분군，게시중약방제적분자작용궤제，병위중약방제적유효성분연구제공일조신도경。
This study was aimed to explain the relationship between chemical component and therapy objective and to identify effective component group (ECG). The objective of this study is to build a new method to identify the ECG. Traditional Chinese medicine (TCM) formula and one of its treated diseases were selected as the re-search object. The entity grammar systems (EGS) were used as the theoretical framework. A grammatical method for ECG identification was constructed. The component-disease relationship was inferred and the ECG was identi-fied with these inference results. In this paper, 16 compounds which act to 12 proteins in Type 1 diabetes melli-tus (T1D) disease network were identified from "Bai-Hu Tang plus Xiao-Ke Fang" and 9 chemical compounds were determined as the candidate effective components group. The results indicated that this method can be used to identify ECG and provide a new way to elucidate the molecular mechanism of TCM formula.