CAJ | 학술논문

目的：观察米力农治疗慢性肺源性心脏病合并心力衰竭的临床疗效。方法将48例慢性肺源性心脏病合并心力衰竭患者分为2组：对照组予以氧疗、抗感染、化痰、平喘、利尿、维持电解质平衡等常规治疗。治疗组在常规治疗基础上加用米力农10 mg于生理盐水250 ml，静脉滴注，于2～3 h内输完，1次/d，5 d为1疗程，观察临床疗效，治疗前后左室射血分数（ LVEF）、每分心排血量（ CO）、每搏量（ SV）、肺动脉压（ PAP）的变化及不良反应。结果治疗组总有效率为91．6％，对照组总有效率为62．5％。2组疗效比较差异具有统计学意义。治疗组患者治疗后的心脏指数、左室射血分数、肺动脉压明显改善，与对照组患者相比差异具有统计学意义。结论在常规治疗基础上加用米力农治疗慢性肺源性心脏病合并心力衰竭是安全有效的，疗效肯定。
목적：관찰미력농치료만성폐원성심장병합병심력쇠갈적림상료효。방법장48례만성폐원성심장병합병심력쇠갈환자분위2조：대조조여이양료、항감염、화담、평천、이뇨、유지전해질평형등상규치료。치료조재상규치료기출상가용미력농10 mg우생리염수250 ml，정맥적주，우2～3 h내수완，1차/d，5 d위1료정，관찰림상료효，치료전후좌실사혈분수（ LVEF）、매분심배혈량（ CO）、매박량（ SV）、폐동맥압（ PAP）적변화급불량반응。결과치료조총유효솔위91．6％，대조조총유효솔위62．5％。2조료효비교차이구유통계학의의。치료조환자치료후적심장지수、좌실사혈분수、폐동맥압명현개선，여대조조환자상비차이구유통계학의의。결론재상규치료기출상가용미력농치료만성폐원성심장병합병심력쇠갈시안전유효적，료효긍정。
Objective To observe the clinical effect of milrinone in treatment of chronic pulmonary heart disease combined with heart failure .Methods 48 cases of chronic pulmonary heart disease with heart failure patients were divided into two groups.The control group was given oxygen therapy ,anti-infection,eliminating phlegm,relieving asthma,diuresis,maintaining electrolyte balance and other conventional treatment .The treatment group , beyond the conventional treatment , was dealt with milrinone infusion 10mg in physiological saline 250ml, within 2~3H, 1/d, 5D for a course of treatment .All observed were clinical curative effect before and after treatment ,left ventricular ejection fraction (LVEF),cardiac output(CO),stroke volume ( SV) ,pulmonary artery pressure ( PAP) changes and adverse reactions .Results The total effective rate of the treatment group was 91.6%in contrast with the control group's 62.5%.There was significant difference in the efficacy of the two groups .After treatment ,the cardiac index , left ventricular ejection fraction ,and pulmonary artery pressure of the treatment group significantly improved compared with the control group .The difference was statistically significant .Conclusion On the basis of convention-al therapy , the treatment of chronic pulmonary heart disease combined with heart failure with milrinone is safe and effective .