国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2014年
6期
420-423
,共4页
郑丽华%张萌萌%赵亚恒%刘运江
鄭麗華%張萌萌%趙亞恆%劉運江
정려화%장맹맹%조아항%류운강
代谢%乳腺肿瘤%雌激素类%腺苷酸活化蛋白激酶
代謝%乳腺腫瘤%雌激素類%腺苷痠活化蛋白激酶
대사%유선종류%자격소류%선감산활화단백격매
Metabolism%Breast neoplasms%Estrogens%Adenosine 5'-monophosphate-activated protein kinase
随着社会发展,肥胖人数越来越多.最近研究表明,肥胖女性乳腺癌风险较正常体重者更高,代谢失常日渐威胁着人类健康.其中雌激素、芳香化酶都促进绝经后乳腺癌的发生、发展.腺苷酸活化蛋白激酶是芳香化酶的负调节物,通过代谢途径能够抑制癌细胞增生,二甲双胍、白藜芦醇通过此途径抑制乳腺癌细胞增生作用已得到证实.本文就绝经后的肥胖相关因子对乳腺组织雌激素合成的作用,以及代谢异常对乳腺中芳香化酶表达的影响作一综述.
隨著社會髮展,肥胖人數越來越多.最近研究錶明,肥胖女性乳腺癌風險較正常體重者更高,代謝失常日漸威脅著人類健康.其中雌激素、芳香化酶都促進絕經後乳腺癌的髮生、髮展.腺苷痠活化蛋白激酶是芳香化酶的負調節物,通過代謝途徑能夠抑製癌細胞增生,二甲雙胍、白藜蘆醇通過此途徑抑製乳腺癌細胞增生作用已得到證實.本文就絕經後的肥胖相關因子對乳腺組織雌激素閤成的作用,以及代謝異常對乳腺中芳香化酶錶達的影響作一綜述.
수착사회발전,비반인수월래월다.최근연구표명,비반녀성유선암풍험교정상체중자경고,대사실상일점위협착인류건강.기중자격소、방향화매도촉진절경후유선암적발생、발전.선감산활화단백격매시방향화매적부조절물,통과대사도경능구억제암세포증생,이갑쌍고、백려호순통과차도경억제유선암세포증생작용이득도증실.본문취절경후적비반상관인자대유선조직자격소합성적작용,이급대사이상대유선중방향화매표체적영향작일종술.
With the social development,the number of obese people is increasing.Recent studies have shown that obese women to have breast cancer disease's risk is higher than normal body weight,and etabolic disorders growing threat to human health.Estrogen,aromatase have contributed to the occurrence and development of breast cancer after menopause.AMPK is a negative regulator of aromatase,it can inhibit proliferation of cancer cells by metabolic pathways.What's more metformin,resveratrol inhibited proliferation by this route has been confirmed in breast cancer cells.Here,the author do an overview of the role of obesity-related factor for postmenopausal breast tissue estrogen synthesis and metabolic abnormalities affect aromatase expression in breast.