CAJ | 학술논문

　　目的：观察蜂蜡麻油敷料对大鼠皮肤溃疡创面愈合的影响。方法：于大鼠背部制备3个缺损性皮肤溃疡，分别设为生理盐水敷料组、凡士林敷料组、蜂蜡麻油敷料组，每2 d换药1次，换药前摄像，每隔1周取标本1次，ELISA测定EGF的含量。结果：第14、21 d时大鼠皮肤创面愈合率，蜂蜡麻油组与其他两组比较有显著差异（P＜0.01和P＜0.05）；第7、14、21 d麻油蜂蜡组创面EGF含量较凡士林组、生理盐水组升高，差异有统计学意义；免疫组化发现麻油蜂蜡组创面细胞中EGF表达增加，定量分析有统计学差异。结论：蜂蜡麻油敷料有促进大鼠皮肤溃疡创面愈合的作用，其机制可能是通过保持湿润和营养来实现的。
　　목적：관찰봉사마유부료대대서피부궤양창면유합적영향。방법：우대서배부제비3개결손성피부궤양，분별설위생리염수부료조、범사림부료조、봉사마유부료조，매2 d환약1차，환약전섭상，매격1주취표본1차，ELISA측정EGF적함량。결과：제14、21 d시대서피부창면유합솔，봉사마유조여기타량조비교유현저차이（P＜0.01화P＜0.05）；제7、14、21 d마유봉사조창면EGF함량교범사림조、생리염수조승고，차이유통계학의의；면역조화발현마유봉사조창면세포중EGF표체증가，정량분석유통계학차이。결론：봉사마유부료유촉진대서피부궤양창면유합적작용，기궤제가능시통과보지습윤화영양래실현적。
Objective To observe the beeswax and benne oil dressing in rat skin ulcer healing. Methods Three skin ulcer wounds were made on the back of the rat, the upper left, the upper right, and the lower left side were set to the saline group, the geoline group and the beeswax and benne oil group respectively. Dressing change was done every two days, photograph taken before dressing, and samples taken at intervals of one week. The epidermal growth factors(EGF) were determined by ELISA. Results On the seventh day, all the three groups on the rate of wound healing were not statistically different (P>0.05).On the fourteenth and twenty-first days, the rate of wound healing was highest in the beeswax and benne oil group, the rate of the beeswax and ben-ne oil group as comparing with those of the other two groups was significantly different(P < 0.01 and P <0.05). On the seventh, fourteenth and twenty-first day of the experiment, the epidermal growth factor was highest in the beeswax and benne oil group, with significant differences from the other two groups. Conclusion Bees-wax and benne oil dressing can promote the skin ulcer healing, beeswax and benne oil can be used as materials of dressing that should be widely used clinically, its effect maybe achieved through keeping wound moist and nu-trition.