CAJ | 학술논문

目的：探讨恙虫病所致肝功能损害的临床特点，为临床诊治恙虫病性肝功能损害提供参考依据。方法：回顾性分析46名恙虫病并发肝功能损害患者病史特点、临床表现、实验室检查等，分析总结恙虫病致肝功能损害患者的临床诊治要点和注意事项。结果：45例患者均有野外活动或坐卧草地史，均有发热，41例出现特征性的焦痂或溃疡。患者血清ALT在82～460U/L之间，AST在65～360U/L之间。使用氯霉素或多西环素等抗恙虫病立克次体并辅以护肝药物治疗，1周后肝功能均有不同程度好转，2～3周后所有患者肝功能基本恢复正常。结论：野外活动或坐卧草地史为恙虫病重要病史特点，出现特征性的焦痂或溃疡为确诊恙虫病重要体征，恙虫病所致肝功能损害一般为轻中度，氯霉素和多西环素可有效控制恙虫病立克次体感染，辅以护肝治疗肝功能一般可顺利恢复正常。
목적：탐토양충병소치간공능손해적림상특점，위림상진치양충병성간공능손해제공삼고의거。방법：회고성분석46명양충병병발간공능손해환자병사특점、림상표현、실험실검사등，분석총결양충병치간공능손해환자적림상진치요점화주의사항。결과：45례환자균유야외활동혹좌와초지사，균유발열，41례출현특정성적초가혹궤양。환자혈청ALT재82～460U/L지간，AST재65～360U/L지간。사용록매소혹다서배소등항양충병립극차체병보이호간약물치료，1주후간공능균유불동정도호전，2～3주후소유환자간공능기본회복정상。결론：야외활동혹좌와초지사위양충병중요병사특점，출현특정성적초가혹궤양위학진양충병중요체정，양충병소치간공능손해일반위경중도，록매소화다서배소가유효공제양충병립극차체감염，보이호간치료간공능일반가순리회복정상。
Objective:To analysis and study of hepatic function lesion with tsutsugamushi disease, to guide the diagnosis and cure for tsutsugamushi disease. Methods:The medical history,clinical manifestation and laboratory examination were analyzed by retrospective research method in 46 patients for past 5 years. Results:45 patients were activity in field or sit on grassland.45 patients were fever. 41 patients were distinctive eschar or ulcer. Liver function was improved in 1 week and normal in 2 or 3 weeks by chloramphenicol or doxycycline with liver aid. Conclusions:Activity in field or sit on grassland was important important. The distinctive eschar or ulcer was important feature for diagnosis of tsutsugamushi disease. The hepatic function lesion with was mild or midrange. Chloramphenicol and doxycycline was effective for tsutsugamushi disease.