CAJ | 학술논문

　　为了解福建黄兔的体温情况以及对细菌内毒素的敏感性状况，探讨其是否适用于家兔的热原实验，按照《中国药典》2010年版中热原检测的标准，对福建黄兔进行体温预检筛查，合格家兔分组耳静脉注射浓度为5、10、20 EU/mL的细菌内毒素国家标准品，分析福建黄兔对内毒素的敏感性。结果表明：福建黄兔预检温筛选合格率为65.85%，体温主要分布于38.5℃~39.5℃。与国内报道的普通级新西兰兔筛选合格率相当，比普通级日本大耳白兔、普通级WHBE兔及SPF级新西兰兔稍低。福建黄兔注射不同浓度的细菌内毒素呈现不同的升温幅度，对细菌内毒素的敏感性与其浓度呈正相关，浓度越大、敏感性越高。通过本实验可知，福建黄兔体温较为恒定，对细菌内毒素也表现出一定的敏感性，若按实验用兔标准饲养，质量将更为稳定，可以探讨应用于热原试验，以拓宽福建黄兔应用价值领域。
　　위료해복건황토적체온정황이급대세균내독소적민감성상황，탐토기시부괄용우가토적열원실험，안조《중국약전》2010년판중열원검측적표준，대복건황토진행체온예검사사，합격가토분조이정맥주사농도위5、10、20 EU/mL적세균내독소국가표준품，분석복건황토대내독소적민감성。결과표명：복건황토예검온사선합격솔위65.85%，체온주요분포우38.5℃~39.5℃。여국내보도적보통급신서란토사선합격솔상당，비보통급일본대이백토、보통급WHBE토급SPF급신서란토초저。복건황토주사불동농도적세균내독소정현불동적승온폭도，대세균내독소적민감성여기농도정정상관，농도월대、민감성월고。통과본실험가지，복건황토체온교위항정，대세균내독소야표현출일정적민감성，약안실험용토표준사양，질량장경위은정，가이탐토응용우열원시험，이탁관복건황토응용개치영역。
To obtain the body temperature instance and sensitivity response to bacterial endotoxin of the Fujian Rabbits, and to discuss whether the Fujian Rabbits could be adapted to suit the use of pyrogen test. According to the standard pyrogen test from‘Chinese Codex’, to choose Fujian Rabbits with the eligible body temperature, which were administrated with three doses of endotoxin (5, 10, 20 Eu/mL) to analyze the sensitivity of these Rabbits response to endotoxin. The 65.85% of the tested Fujian Rabbits were up to the mustard and the body temperature of most Rabbits was 38.5-39.5℃. The eligibity whereas under the Japanes White rabbit, WHBE and SPF New Zealand Rabbits. The sensitivity of the Fujian Rabbits reponse to bacterial endotoxin was positive correlativity to the dose of endotoxin, the big dose resulted to the high sensitivity. Through the test, it was known that most of the Fujian Rabbits’body temperature was steady, which had some sensitivity to the bacterial endotoxin. If the Fujian Rabbits were fed in a standard way of laboratory animal, the quality of Rabbits would more stable, and these Rabbits would fit for the pyrogen test, which could broaden out the Fujian Rabbits' application field.