CAJ | 학술논문

　　目的超敏C反应蛋白（hs-CRP）与胆固醇比上高密度脂蛋白胆固醇的值（COL/HDL-C）在糖尿病、心血管疾病中的作用。方法超敏C反应蛋白的测定采用胶乳免疫比浊法，总胆固醇、三酰甘油、高密度与低密度脂蛋白胆固醇的测定采用一步法和氧化酶法。结果 COL/HDL-C，hs-CRP在高血压组，急性心肌梗死组（AMI）和冠心病组（CAD）与健康对照组比较，均显著升高（P＜0.01）。并且急性梗死组（AMI）显著高于冠心病（CAD）组（P＜0.01），冠心病组（CAD）高于高血压组（P＜0.05）。结论 hs-CRP浓度和糖尿病、心血管疾病及其病变程度明显相关，同时检测hs-CRP与TC/HDL-C能提高对糖尿病和心血管疾病的预测以及危险程度的评估。
　　목적초민C반응단백（hs-CRP）여담고순비상고밀도지단백담고순적치（COL/HDL-C）재당뇨병、심혈관질병중적작용。방법초민C반응단백적측정채용효유면역비탁법，총담고순、삼선감유、고밀도여저밀도지단백담고순적측정채용일보법화양화매법。결과 COL/HDL-C，hs-CRP재고혈압조，급성심기경사조（AMI）화관심병조（CAD）여건강대조조비교，균현저승고（P＜0.01）。병차급성경사조（AMI）현저고우관심병（CAD）조（P＜0.01），관심병조（CAD）고우고혈압조（P＜0.05）。결론 hs-CRP농도화당뇨병、심혈관질병급기병변정도명현상관，동시검측hs-CRP여TC/HDL-C능제고대당뇨병화심혈관질병적예측이급위험정도적평고。
Objective?To investigate the role of high-sensitivity C-reactive protein (hs-CRP) and ratio of total cholesterol to HDL-cholesterol (TC/HDL-C) in cardiovascular disease. Methods hs-CRP was determined by latex –enhanced immunoturbidimetric assay, TG, TC, HDL-C, LDL-C was determined by enzyme methods and homogeneous method. Results The level of hs-CRP and TC/HDL-C in patients were significantly higher than in the controls. The level of hs-CRP and TC/HDL-C in active myocardial infarction(AMI)was significantly higher than in the coronary artery disease(CAD). The level of hs-CRP and TC/HDL-C in CAD was significantly higher than in hypertension patient. Conclusions Hs-CRP was strongly associated with cardiovascular disease. It is the stronger risk assessment and predictor of diabetes mellitus and cardiovascular using both hs-CRP and TC/HDL-C ratio.