CAJ | 학술논문

　　目的了解我院药品不良反应（ADR）发生的特点，促进临床合理用药。方法收集我院2012年1～12月130例ADR报告进行统计分析。结果静脉给药发生ADR101例；子宫腔内给药引起ADR 5例。丙泊酚注射液静脉麻醉时，发生皮肤红斑、红疹67例，其中2例发生严重ADR。抗菌药物26例；妇产科等性激素类药物9例；维生素及微量元素类药物8例。结论2012年抗菌药物ADR发生率较2007年下降62.86%，随着其使用量的减少，ADR发生率也大幅下降。针对我院专科特点，应加强静脉用麻醉药、妇产科等性激素类、维生素及微量元素类药物、止血药、口服中成药等ADR的监测，尽量减少静脉给药，关注子宫腔内注射给药引起的ADR。应按照说明书合理使用每一种药品，保证用药安全。
　　목적료해아원약품불량반응（ADR）발생적특점，촉진림상합리용약。방법수집아원2012년1～12월130례ADR보고진행통계분석。결과정맥급약발생ADR101례；자궁강내급약인기ADR 5례。병박분주사액정맥마취시，발생피부홍반、홍진67례，기중2례발생엄중ADR。항균약물26례；부산과등성격소류약물9례；유생소급미량원소류약물8례。결론2012년항균약물ADR발생솔교2007년하강62.86%，수착기사용량적감소，ADR발생솔야대폭하강。침대아원전과특점，응가강정맥용마취약、부산과등성격소류、유생소급미량원소류약물、지혈약、구복중성약등ADR적감측，진량감소정맥급약，관주자궁강내주사급약인기적ADR。응안조설명서합리사용매일충약품，보증용약안전。
Objective To understand the characteristics of adverse drug reaction (ADR) of authors’ hospital, to stipulate the rational drug usage in clinic. Methods 130 ADR cases of authors’ hospital, dated from January to December of 2012, have been collected and analyzed. Result 101 ADR cases are caused by intravenous injection; 5 ADR cases are caused by uterine cavity; 67 cases are caused by intravenous anesthetic propofol injection which leads to the occurrence of skin erythema, including two cases of serious ADR; There are 26 cases of antimicrobial agents; there are 9 cases of obstetrics and gynecology and other hormone related drugs; there are 8 cases of vitamins and tiny elements of drugs cases, and so on. Conclusion Compared to 2007, the antimicrobial ADR incidence rate decreased by 62.86 percent in 2012. While usage of antimicrobial drugs reduces, the ADR incidence also declined substantially. According to the characteristics of authors’ hospital profession, ADR monitoring should be strengthened on the usage of intravenous anesthetics, obstetrics and gynecology, sex hormones, vitamins and tiny elements of drugs, hemostatic, oral proprietary. It is better to minimize intravenous injection, to concern about the uterine cavity injection to drugs which leads to ADR. It is important to keep rational and safe usage on drug in accordance with the instructions.