CAJ | 학술논문

　　目的研究及探讨高氧液在治疗大鼠急性颅脑损伤模型中的疗效及其机制，为进一步研究新的治疗颅脑创伤的技术而奠定基础。方法以不同冲击力，制作轻、中、重度弥漫性脑损伤动物模型（N=20），分别给予以高氧液（20mg/kg），静脉注射，取脑脊液分析S-100B的浓度。结果①不同级别脑损伤组的S-100B蛋白水平较正常组明显上调（P＜0.01），且在不同程度颅脑外伤组中，S-100B蛋白的变化与颅脑外伤严重程度呈正性相关（P＜0.01）；②各组均以20mg/kg为标准量分别给予高氧液后，各治疗组S-100B蛋白水平均较其对应的损伤组明显降低（P＜0.01），且各组间S-100B蛋白的水平无明显差异。结论 S－100 B 蛋白在临床上可作为可靠参数加以参考。至于它参与脑损伤机制的研究，则有待于我们进一步研究。
　　목적연구급탐토고양액재치료대서급성로뇌손상모형중적료효급기궤제，위진일보연구신적치료로뇌창상적기술이전정기출。방법이불동충격력，제작경、중、중도미만성뇌손상동물모형（N=20），분별급여이고양액（20mg/kg），정맥주사，취뇌척액분석S-100B적농도。결과①불동급별뇌손상조적S-100B단백수평교정상조명현상조（P＜0.01），차재불동정도로뇌외상조중，S-100B단백적변화여로뇌외상엄중정도정정성상관（P＜0.01）；②각조균이20mg/kg위표준량분별급여고양액후，각치료조S-100B단백수평균교기대응적손상조명현강저（P＜0.01），차각조간S-100B단백적수평무명현차이。결론 S－100 B 단백재림상상가작위가고삼수가이삼고。지우타삼여뇌손상궤제적연구，칙유대우아문진일보연구。
Objective To discuss and research the mechanism and effect of hyperoxic fluid in acute traumatic model of rat so as to lay the foundation for the new method of clinic treatment. Method Mild moderate, severe group was divided by different impact. Every group was injected with hyperoxic fluid (20mg/kg) from vein. .Result ①The expression of S-100B protein of every traumatic group is up-regulated obviously. ②After injection with hyperoxic fluid(20mg/kg), the expression of S-100B of every treatment group is down-regulated significantly(P<0.01),and Between every group ,the expression of S-100B is not obviously(P>0.05). Conclusion The S-100 B protein in clinical parameters can be used as a reliable reference. As it is involved in the mechanism of brain damage, then we need to be studied further.