中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
16期
14-15
,共2页
感音神经性耳聋%基于体素的形态学测量%VBM%灰质
感音神經性耳聾%基于體素的形態學測量%VBM%灰質
감음신경성이롱%기우체소적형태학측량%VBM%회질
Deaf and normal%Voxel-based morphological measurements%Magnetic resonance%Gray and white matter
目的利用基于体素形态学技术分析听力正常人志愿者与感音神经性耳聋患者之间的脑灰质差异。方法分别对24例听力正常人及24例感音神经性耳聋人进行常规T2-WI与三维（3D）快速扰相梯度回波（fast spoiled gradient echo，FSPGR）采集脑结构图像。用VBM技术运算，然后观察两组之间的脑质差异并显示出差异脑区的MNI坐标及差异容积，然后对所得数据进行相应统计学分析。结果感音神经性耳聋组脑灰质增多的区域有（P＜0.01，Cluster size=40）：左侧颞上回、右侧颞上回、左侧额下回、左侧中央前回、左侧中央后回、左侧扣带回、左侧小脑半球、左侧顶下小叶、左侧屏状核、左侧小脑前叶、右侧小脑前叶、右侧小脑后叶、右侧额下回。结论感音神经性聋人在左、右侧颞上回灰质增多，提示其听觉中枢皮质有结构重组。
目的利用基于體素形態學技術分析聽力正常人誌願者與感音神經性耳聾患者之間的腦灰質差異。方法分彆對24例聽力正常人及24例感音神經性耳聾人進行常規T2-WI與三維（3D）快速擾相梯度迴波（fast spoiled gradient echo，FSPGR）採集腦結構圖像。用VBM技術運算，然後觀察兩組之間的腦質差異併顯示齣差異腦區的MNI坐標及差異容積，然後對所得數據進行相應統計學分析。結果感音神經性耳聾組腦灰質增多的區域有（P＜0.01，Cluster size=40）：左側顳上迴、右側顳上迴、左側額下迴、左側中央前迴、左側中央後迴、左側釦帶迴、左側小腦半毬、左側頂下小葉、左側屏狀覈、左側小腦前葉、右側小腦前葉、右側小腦後葉、右側額下迴。結論感音神經性聾人在左、右側顳上迴灰質增多，提示其聽覺中樞皮質有結構重組。
목적이용기우체소형태학기술분석은력정상인지원자여감음신경성이롱환자지간적뇌회질차이。방법분별대24례은력정상인급24례감음신경성이롱인진행상규T2-WI여삼유（3D）쾌속우상제도회파（fast spoiled gradient echo，FSPGR）채집뇌결구도상。용VBM기술운산，연후관찰량조지간적뇌질차이병현시출차이뇌구적MNI좌표급차이용적，연후대소득수거진행상응통계학분석。결과감음신경성이롱조뇌회질증다적구역유（P＜0.01，Cluster size=40）：좌측섭상회、우측섭상회、좌측액하회、좌측중앙전회、좌측중앙후회、좌측구대회、좌측소뇌반구、좌측정하소협、좌측병상핵、좌측소뇌전협、우측소뇌전협、우측소뇌후협、우측액하회。결론감음신경성롱인재좌、우측섭상회회질증다，제시기은각중추피질유결구중조。
Objective To comparied the cerebral gray matter of the normal hearing subjects and the sensorineural deafness patients with voxel-based morphology. Methods Both the normal hearing group and the sensorineural deafness group were scaned with GE 3.0T MRI scaner to get routine T2WI and three-dimensional (3D) fast spoiled gradient echo (fast spoiled gradient echo, FSPGR) collection of brain structures image. Observed qualitative differences of the brain with VBM between the two groups and demonstrate the differences between the MNI coordinates of brain regions and the differences in volume, and then statistically analyzed the data accordingly. Result The increasing areas of gray matter in sensorineural hearing loss patients(P< 0.001,Cluster size=50): the left superior temporal gyrus, right superior temporal gyrus, left inferior frontal gyrus, left precentral gyrus, left, after the central back, left cingulate gyrus, left lateral cerebellar hemispheres, the left wedge leaf, the left inferior parietal lobule, the left claustrum, the left cerebellar anterior lobe, right cerebellar anterior lobe, right behind the small leaf, the right inferior frontal gyrus. Conclusion The increased gray matter of Sensorineural deaf are in the left and right superior temporal gyrus, indicating its structural reorganization of auditory cortex.
