实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
10期
1652-1654
,共3页
头颈部肿瘤%适形调强放疗%黄芪多糖
頭頸部腫瘤%適形調彊放療%黃芪多糖
두경부종류%괄형조강방료%황기다당
Cervicocerebral tumor%IMRT%Astragalus Polysaccharide
目的：观察适形调强放射治疗联合黄芪多糖注射液治疗头颈部肿瘤的疗效、免疫力情况及毒副反应的临床研究。方法：观察61例初治头颈部肿瘤患者随机分为适形调强放疗联合黄芪多糖组（30例）和适形调强放疗组（31例），观察并比较两组近期疗效、免疫力情况及毒副反应，放疗前后T细胞亚群、自然杀伤（NK）细胞活性的变化，以及观察放疗中、后患者出现的皮炎及口腔黏膜反应、口干等情况。结果：实验组和对照组的总有效率分别为83．0％和80．6％。适形调强放疗联合黄芪多糖组外周血淋巴细胞及NK细胞活性增高，T3、T4、NK细胞值增高（P＜0．05），对照组治疗前后外周血T3、T4、NK细胞值降低（P＜0．05），黏膜反应和皮炎、口干在治疗3周后实验组明显好与对照组（P＜0．05）。结论：黄芪多糖可以可以提高患者机体的免疫水平，降低适形调强放射治头颈部肿瘤患者放疗的副作用。
目的：觀察適形調彊放射治療聯閤黃芪多糖註射液治療頭頸部腫瘤的療效、免疫力情況及毒副反應的臨床研究。方法：觀察61例初治頭頸部腫瘤患者隨機分為適形調彊放療聯閤黃芪多糖組（30例）和適形調彊放療組（31例），觀察併比較兩組近期療效、免疫力情況及毒副反應，放療前後T細胞亞群、自然殺傷（NK）細胞活性的變化，以及觀察放療中、後患者齣現的皮炎及口腔黏膜反應、口榦等情況。結果：實驗組和對照組的總有效率分彆為83．0％和80．6％。適形調彊放療聯閤黃芪多糖組外週血淋巴細胞及NK細胞活性增高，T3、T4、NK細胞值增高（P＜0．05），對照組治療前後外週血T3、T4、NK細胞值降低（P＜0．05），黏膜反應和皮炎、口榦在治療3週後實驗組明顯好與對照組（P＜0．05）。結論：黃芪多糖可以可以提高患者機體的免疫水平，降低適形調彊放射治頭頸部腫瘤患者放療的副作用。
목적：관찰괄형조강방사치료연합황기다당주사액치료두경부종류적료효、면역력정황급독부반응적림상연구。방법：관찰61례초치두경부종류환자수궤분위괄형조강방료연합황기다당조（30례）화괄형조강방료조（31례），관찰병비교량조근기료효、면역력정황급독부반응，방료전후T세포아군、자연살상（NK）세포활성적변화，이급관찰방료중、후환자출현적피염급구강점막반응、구간등정황。결과：실험조화대조조적총유효솔분별위83．0％화80．6％。괄형조강방료연합황기다당조외주혈림파세포급NK세포활성증고，T3、T4、NK세포치증고（P＜0．05），대조조치료전후외주혈T3、T4、NK세포치강저（P＜0．05），점막반응화피염、구간재치료3주후실험조명현호여대조조（P＜0．05）。결론：황기다당가이가이제고환자궤체적면역수평，강저괄형조강방사치두경부종류환자방료적부작용。
Objective To observe the effect of IMRT combined with astragalus polysaccharide (ASP) injection on cervicocerebral tumor,radiation side effects and its influence on immune function. Methods 61 head and neck tumor patients were randomly divided into two groups.One groups received the IMRT combined with Astragalus Polysaccharide (ASP) injection (n=30) while the other group only received the IMRT(n=31). The recent effect, immune function and the side effects of radiotherapy between the 2 groups were observed and compared , changes of T-lymphocyte subsets, natural killer (NK) cell activity and the dermatitis,oral mucosa reaction,thirsty condition on patients in intraoperative or postoperative period were also observed and compared. Results The total effective rate in experimental group and the control group were 83.0% and 80.6% respectively.The cell viability of peripheral blood lymphocyte and NK cell as well as the T3、T4、NK cell value increased in IMRT-ASP group (P<0.05) after treatment. While T3、T4、NK cell value in peripheral blood decreased (P<0.05). Mucosa,dermatitis and salivary gland damage showed in IMRT-ASP group were significantly better than in control group after 3 weeks treatment (P<0.05). Conclusion ASP can improve immune function effect in head and neck tumor patients during RT, and can also eliminate the side effects of radiotherapy.
