CAJ | 학술논문

目的：探讨沙格列汀与二甲双胍治疗2型糖尿病(T2DM)的临床疗效、安全性以及用药依从性。方法选择我院收治的2型糖尿病患者为研究对象，随机分为沙格列汀组和二甲双胍组，分别给予沙格列汀和二甲双胍控制血糖，观察并记录两组患者治疗前后空腹血糖( FBG)、餐后2 h 血糖( PG2h)、糖化血红蛋白(HbA1c)、低血糖发生率、肝肾功能、体重变化情况，同时对两组患者用药的依从性进行对比分析。结果两组总有效率比较差异无统计学意义(P>0．05)，但沙格列汀组显效率明显高于二甲双胍组，差异有统计学意义(P<0．05)。治疗12周后，沙格列汀组患者 FBG、PG2h、HbA1c 水平均较治疗前明显改善(P <0．01)；二甲双胍组FBG、PG2h较治疗前明显改善(P<0．01)，但HbA1c水平较治疗前改善不明显(P>0．05)。沙格列汀组治疗后FBG、PG2h、HbA1c改善程度均明显优于二甲双胍组，差异均有统计学意义(P<0．01)。两组患者治疗前后血谷丙转氨酶( ALT)、谷草转氨酶( AST)、血尿素氮( BUN)、血肌酐( Scr)等肝肾功能检查指标差异均无统计学意义(P>0．05)，两组治疗12周后体重指数与治疗前比较差异无统计学意义(P>0．05)。两组患者用药期间不良反应发生率比较差异无统计学意义(P>0．05)，且症状较轻微，均经对症处理后缓解。格列汀组患者用药依从性明显高于二甲双胍组，差异有统计学意义(P<0．05)。结论沙格列汀能有效控制2型糖尿病患者的血糖，降低糖化血红蛋白水平，同时对肝肾功能、体重等无明显影响，且不良反应少，但由于沙格列汀为新药，临床试验随访时间较短，其远期疗效、安全性以及患者的耐药性仍需进行长期的大样本研究加以证实。
목적：탐토사격렬정여이갑쌍고치료2형당뇨병(T2DM)적림상료효、안전성이급용약의종성。방법선택아원수치적2형당뇨병환자위연구대상，수궤분위사격렬정조화이갑쌍고조，분별급여사격렬정화이갑쌍고공제혈당，관찰병기록량조환자치료전후공복혈당( FBG)、찬후2 h 혈당( PG2h)、당화혈홍단백(HbA1c)、저혈당발생솔、간신공능、체중변화정황，동시대량조환자용약적의종성진행대비분석。결과량조총유효솔비교차이무통계학의의(P>0．05)，단사격렬정조현효솔명현고우이갑쌍고조，차이유통계학의의(P<0．05)。치료12주후，사격렬정조환자 FBG、PG2h、HbA1c 수평균교치료전명현개선(P <0．01)；이갑쌍고조FBG、PG2h교치료전명현개선(P<0．01)，단HbA1c수평교치료전개선불명현(P>0．05)。사격렬정조치료후FBG、PG2h、HbA1c개선정도균명현우우이갑쌍고조，차이균유통계학의의(P<0．01)。량조환자치료전후혈곡병전안매( ALT)、곡초전안매( AST)、혈뇨소담( BUN)、혈기항( Scr)등간신공능검사지표차이균무통계학의의(P>0．05)，량조치료12주후체중지수여치료전비교차이무통계학의의(P>0．05)。량조환자용약기간불량반응발생솔비교차이무통계학의의(P>0．05)，차증상교경미，균경대증처리후완해。격렬정조환자용약의종성명현고우이갑쌍고조，차이유통계학의의(P<0．05)。결론사격렬정능유효공제2형당뇨병환자적혈당，강저당화혈홍단백수평，동시대간신공능、체중등무명현영향，차불량반응소，단유우사격렬정위신약，림상시험수방시간교단，기원기료효、안전성이급환자적내약성잉수진행장기적대양본연구가이증실。
Objective To investigate the clinical efficacy,safety and medication compliance of onglyza and metformin treatment for type 2 diabetes. Methods Type 2 diabetes patients in our hospital were chose as the research object,and were randomly divided into onglyza group and metformin group,the fasting blood glucose (FBG),2 h post-prandial blood glucose (PG2h),glycosylated hemoglobin (HbA1c),the incidence of hypoglycemia,liver and kidney function,weight change of the two groups were recorded and compared and the medication compliance of the two groups were analyzed. Results The total effective rate of the two groups had no significant difference (P>0. 05),but the significant efficiency of onglyza group was obviously higher than that of metformin group, there was significant difference between the two groups (P<0. 05). After 12 weeks treatment,the FBG,PG2h and HbA1c level of onglyza group were significantly improved than before treatment (P <0. 01);The FBG and PG2h level of metformin group were significantly improved than before treatment (P<0. 01),but the HbA1c level improvement was not obvious (P>0. 05). The FBG,PG2h,HbA1c improvement degree of onglyza group were significantly superior to that of metformin group,there was significant difference between the two groups (P<0. 01). The liver and kidney function of the two groups had no significant difference(P>0. 05),and the body mass index of the two groups had no significant change after the 12 weeks treatment,there was no difference between the two groups (P>0. 05). The adverse reactions inci-dence during the medication of the two groups had no significant difference between the two goups (P>0. 05),and the symptoms was mild,they were all eased up after symptomatic treatment. The medication compliance of onglyza group was significantly higher than that of metformin group,the difference was significant (P<0. 05). Conclusion Onglyza can effectively control the blood sugar of type 2 diabetes,lower glycosylated hemoglobin level,has no obvious effect on liver and kidney function,weight,etc,and the adverse reaction is mild,but onglyza is a new drug,the long-term effica-cy,safety needs to be confirmed by large sample research for a long term.