CAJ | 학술논문

　　目的观察来氟米特对多发性硬化(MS)的作用，为临床治疗MS提供新途径，并为后续的类似免疫制剂的研究开发提供实验模式。方法将符合标准的42例患者，随机分为对照组18例和实验组24例，对照组采用传统激素治疗，实验组采用来氟米特联合小剂量地塞米松治疗，比较两组的有效率及各自血清TNF-α与尿酸水平，并进行统计学分析。结果实验组有效率与尿酸水平高于对照组，血清TNF-α水平低于对照组，并有统计学差异（P <0.05）。结论来氟米特治疗多发性硬化有一定疗效，可减轻多发性硬化的发病程度与促进其恢复。
　　목적관찰래불미특대다발성경화(MS)적작용，위림상치료MS제공신도경，병위후속적유사면역제제적연구개발제공실험모식。방법장부합표준적42례환자，수궤분위대조조18례화실험조24례，대조조채용전통격소치료，실험조채용래불미특연합소제량지새미송치료，비교량조적유효솔급각자혈청TNF-α여뇨산수평，병진행통계학분석。결과실험조유효솔여뇨산수평고우대조조，혈청TNF-α수평저우대조조，병유통계학차이（P <0.05）。결론래불미특치료다발성경화유일정료효，가감경다발성경화적발병정도여촉진기회복。
Objective: Observing the effect of leflunomide on multiple sclerosis , to provide a new way for the clinical treatment of MS, and to provide the experimental model for subsequent similar immune preparation research and development. Methods 42 patients with MS, were randomly divided into control group of 18 cases and 24 cases in experimental group, the control group used traditional hormone therapy, the experimental group used leflunomide combined with smal dose of dexamethasone treatment, then compared the efficiency and their serum TNF- α and uric acid levels in two groups, make a statistical analysis in addition. Results The experimental group's efficiency and uric acid levels was higher than the control group, the serum TNF- α level was lower than that of the control group, and there were significant differences (P<0.05).Conclusion Leflunomide in the treatment of multiple sclerosis have certain curative effect, it can reduce the incidence of multiple sclerosis and promote the recovery.