CAJ | 학술논문

目的探讨利培酮治疗不同型精神分裂症的疗效及安全性.方法收集100例偏执型及未分化型精神分裂症患者,分别给予利培酮治疗,观察8周,分别于治疗前及治疗第1,2,4,6,8周末分别进行阳性和阴性症状量表(PANSS)、临床总体印象量表、不良反应量表、锥体外系不良反应量表评分,比较不同型精神分裂症患者对利培酮的疗效及不良反应.结果不同型精神分裂症患者治疗后同一时间点PANSS评分比较差异无统计学意义(P＞0.05)；不同型精神分裂症患者同一时间点所用剂量比较差异无统计学意义(P＞0.05)；利培酮治疗前后PANSS评分比较差异有统计学意义(P＜0.01)；入组前体重基线值为(63.91±11.75) kg,治疗8周后为(65.48±10.92) kg,差异有统计学意义(P＜0.01).结论利培酮对偏执型及未分化型精神分裂症疗效肯定,并具有较好的安全性及耐受性.
목적 탐토리배동치료불동형정신분렬증적료효급안전성.방법 수집100례편집형급미분화형정신분렬증환자,분별급여리배동치료,관찰8주,분별우치료전급치료제1,2,4,6,8주말분별진행양성화음성증상량표(PANSS)、림상총체인상량표、불량반응량표、추체외계불량반응량표평분,비교불동형정신분렬증환자대리배동적료효급불량반응.결과 불동형정신분렬증환자치료후동일시간점PANSS평분비교차이무통계학의의(P＞0.05)；불동형정신분렬증환자동일시간점소용제량비교차이무통계학의의(P＞0.05)；리배동치료전후PANSS평분비교차이유통계학의의(P＜0.01)；입조전체중기선치위(63.91±11.75) kg,치료8주후위(65.48±10.92) kg,차이유통계학의의(P＜0.01).결론 리배동대편집형급미분화형정신분렬증료효긍정,병구유교호적안전성급내수성.
Objective To explore the safety and efficacy of risperidone in treatment of different kinds of schizophrenia.Methods Collected 100 cases of paranoid and undifferentiated schizophrenia patients,all patients were given risperidone treatment and observed for 8 weeks.Before treatment and at the 1st,2nd,4th,6th,8th weeks respectively by means of positive and negative symptom scale (PANSS),the Clinical Global Impression scale,adverse reaction scale,extrapyramidal system adverse reactions to scale score,comparison of different types of schizophrenia patients on risperidone' s efficacy and adverse reaction.Results The total PANSS score of different kinds of schizophrenia didn' t have great difference (P＞0.05); the dose also didn' t have great statistical difference between different kinds of schizophrenia (P＞0.05); the total PANSS score had great statistical difference between treatment (P＜0.01); the group before the baseline weight value was (63.91 ± 11.75) kg,after 8 weeks of treatment it was (65.48 ± 10.92) kg,the difference was statistically significant.Conclusion Risperidone has curative effect on paranoid and undifferentiated schizophrenia,and with good safety and tolerance.