CAJ | 학술논문

　　目的：探讨eIF4E蛋白表达在大肠癌发生发展中的作用和诊断意义。方法：用免疫组化方法检测145例大肠石蜡标本的eIF4E表达。病例包括大肠炎25例、腺瘤40例、腺癌40例、转移性腺癌40例。结果：依大肠炎、腺瘤、腺癌、转移性腺癌的次序,eIF4E阳性表达率分别为12.0%、80.0%、85.0%、100%，其中大肠炎组分别与其他三组比较，P<0.01；腺瘤组与腺癌组比较，P>0.05；腺瘤组和腺癌组分别与转移性腺癌组比较，P<0.05。依I、II、III、IV临床分期次序， eIF4E阳性表达率分别为62.5%、82.8%、96.6%、100%，P<0.01。eIF4E阳性表达与性别、年龄、发生部位、浸润深度、分化程度等无关。eIF4E阳性表达从大肠炎中诊断腺瘤的敏感性为85.0%，特异性为88.0%；从腺瘤中诊断腺癌的敏感性为92.5%，特异性为17.7%。结论：eIF4E在大肠粘膜演变成腺瘤和腺癌、从未转移性腺癌演变成转移性腺癌、从早期癌到晚期癌中表达显著升高，提示eIF4E可以促进大肠肿瘤的发生发展，具有潜在的预后和诊断价值。
　　목적：탐토eIF4E단백표체재대장암발생발전중적작용화진단의의。방법：용면역조화방법검측145례대장석사표본적eIF4E표체。병례포괄대장염25례、선류40례、선암40례、전이성선암40례。결과：의대장염、선류、선암、전이성선암적차서,eIF4E양성표체솔분별위12.0%、80.0%、85.0%、100%，기중대장염조분별여기타삼조비교，P<0.01；선류조여선암조비교，P>0.05；선류조화선암조분별여전이성선암조비교，P<0.05。의I、II、III、IV림상분기차서， eIF4E양성표체솔분별위62.5%、82.8%、96.6%、100%，P<0.01。eIF4E양성표체여성별、년령、발생부위、침윤심도、분화정도등무관。eIF4E양성표체종대장염중진단선류적민감성위85.0%，특이성위88.0%；종선류중진단선암적민감성위92.5%，특이성위17.7%。결론：eIF4E재대장점막연변성선류화선암、종미전이성선암연변성전이성선암、종조기암도만기암중표체현저승고，제시eIF4E가이촉진대장종류적발생발전，구유잠재적예후화진단개치。
Objective: To explore the role of eIF4E in occurrence and development of colorectal tumors and the diagnosis value of the eIF4E expression. Methods: Immunohistochemistry was used to detect the eIF4E expression in 145 cases of colorectal tissues. The cases included 25 colitis, 40 adenomas, 40 adenocarcinomas and 40 metastatic adeno-carcinomas. Results:In the order of colitis, adenoma, adenocarcinoma and metastatic adenocarcinoma, the eIF4E expression rates were 12.0%, 80.0%, 85.0% and 100%,respectively, P<0.01 between colitis and the three tumor groups, P>0.05 between adenoma and adenocarcinoma, and P<0.05 between adenoma and adenocarcinoma and metastatic adenocarcinoma. In the order of the clinical phase I, I, II and IV of the malignancies, the expression rates of eIF4E were 62.5%、82.8%、96.6%、100%,respectively, P<0.01. There was no significant difference between the expression of eIF4E and the age and gender of the patients, and the location, invasive deepness and differentiation of the malignancies. For the eIF4E expression to diagnose adenoma from colitis, the sensitivity was 85.0% and the specificity was 88.0%. For the eIF4E expression to diagnose adenocarcinoma from adenoma, the sensitivity was 92.5% and the specificity was 17.7%. Conclusion: The expression of eIF4E significantly increases during the evolution from colitis to adenoma and then adenocarcinoma, from adenocarcinoma to metastatic adenocarcinoma, and from the early phase to the late phase of colorectal carcinoma. The result indicated that eIF4E may initiate and promote cololectal adenocarcinoma, and the expression of eIF4E might have a potential value to diagnose and prognoses colorectal tumors.