CAJ | 학술논문

　　目的探讨不同病理类型胃息肉和胃癌中RASAL1基因的表达变化及临床意义。方法对正常胃黏膜组40例、增生性胃息肉组35例、腺瘤性息肉组30例及胃癌组40例采用免疫组化SP染色法检测RASAL1蛋白的表达情况。结果胃癌组RASAL1蛋白的阳性率为17.50%，明显低于正常胃黏膜组（95.00%）、增生性胃息肉组（85.71%）及腺瘤性息肉组（53.33％），差异均有统计学意义（P<0.05）；增生性息肉组中RASAL1蛋白阳性率与性别、年龄、生长部位及息肉大小均无相关性（P<0.05）；腺瘤性息肉组中RASAL1蛋白阳性率与性别、年龄、生长部位均无相关性（P<0.05），而与息肉大小有相关性(P<0.05)。结论检测胃息肉和胃癌中RASAL1基因的表达有助于推测胃息肉的生物学行为发展趋势，从而早期诊断胃癌并判断其预后。
　　목적탐토불동병리류형위식육화위암중RASAL1기인적표체변화급림상의의。방법대정상위점막조40례、증생성위식육조35례、선류성식육조30례급위암조40례채용면역조화SP염색법검측RASAL1단백적표체정황。결과위암조RASAL1단백적양성솔위17.50%，명현저우정상위점막조（95.00%）、증생성위식육조（85.71%）급선류성식육조（53.33％），차이균유통계학의의（P<0.05）；증생성식육조중RASAL1단백양성솔여성별、년령、생장부위급식육대소균무상관성（P<0.05）；선류성식육조중RASAL1단백양성솔여성별、년령、생장부위균무상관성（P<0.05），이여식육대소유상관성(P<0.05)。결론검측위식육화위암중RASAL1기인적표체유조우추측위식육적생물학행위발전추세，종이조기진단위암병판단기예후。
Objective To observe the expression of RASAL1 gene in different types of gastric polyp and gastric carcinoma. Methods The expression of RASAL1 gene were examined using immunohistochemical staining in normal gastric mucosa group(n=40) and proliferative polyp group(n=35) and adenomatous polyp group(n=30) and gastric carcinoma group(n=40). Results The positive rates of RASAL1 gene in gastric carcinoma group were obviously lower than that in other groups (P<0.05). In proliferative and adenomatous polyp groups, the positive rates of RASAL1 gene were not relevant to the sex, age and polyp site(P>0.05), and were closely relevant to the size of polyp in the adenomatous polyp group (P<0.05) but not in the proliferative polyp group (P>0.05). Conclusion Detection of RASAL1 gene was helpful to determining the development and biological behavior of gastric polyps, early diagnosis and prognosis of gastric carcinoma.