CAJ | 학술논문

　　目的：探讨莫西沙星、卷曲霉素方案治疗耐多药肺结核的临床疗效。方法：选取2011年6月-2012年6月于笔者所在医院进行治疗的52例耐多药肺结核患者为研究对象，将其随机分为对照组(左氧氟沙星、卷曲霉素组)26例和观察组(莫西沙星、卷曲霉素组)26例，然后将两组患者不同时间的痰菌转阴率、不良反应发生率及治疗前后的肝功能指标进行比较。结果：观察组不同时间的痰菌转阴率均高于对照组，不良反应发生率低于对照组，而治疗后的各项肝功能指标则均低于对照组，差异均有统计学意义(P<0.05)。结论：莫西沙星、卷曲霉素方案治疗耐多药肺结核的临床疗效较好，且对机体的不良影响相对更小。
　　목적：탐토막서사성、권곡매소방안치료내다약폐결핵적림상료효。방법：선취2011년6월-2012년6월우필자소재의원진행치료적52례내다약폐결핵환자위연구대상，장기수궤분위대조조(좌양불사성、권곡매소조)26례화관찰조(막서사성、권곡매소조)26례，연후장량조환자불동시간적담균전음솔、불량반응발생솔급치료전후적간공능지표진행비교。결과：관찰조불동시간적담균전음솔균고우대조조，불량반응발생솔저우대조조，이치료후적각항간공능지표칙균저우대조조，차이균유통계학의의(P<0.05)。결론：막서사성、권곡매소방안치료내다약폐결핵적림상료효교호，차대궤체적불량영향상대경소。
Objective:To study the clinical effect of moxifloxacin and capreomycin prescription in the treatment of multi-drug resistant pulmonary tuberculosis.Methods:52 patients with multi-drug resistant pulmonary tuberculosis in our hospital from June 2011 to June 2012 were selected as research object, and they were randomly divided into control group(levofloxacin and capreomycin group)26 cases and observation group(moxifloxacin and capreomycin group)26 cases,then the sputum negative conversion rate at different times,incidence of adverse reaction and liver function indexes before and after the treatment at different times of two groups were compared.Results:The sputum negative conversion rates of observation group at different times were higher than those of control group,incidence of adverse reaction was lower than that of control group,liver function indexes after the treatment at different times were all lower than those of control group too,there were all significant differences(P<0.05).Conclusion:The moxifloxacin and capreomycin prescription in the treatment of multi-drug resistant pulmonary tuberculosis is better,and its bad influence for the body is relatively smaller.