CAJ | 학술논문

　　目的：观察局部晚期宫颈癌新辅助化疗的临床治疗效果。方法：选取笔者所在医院2010-2012年收治的局部晚期宫颈癌患者20例，其中Ⅰb2期的患者6例，Ⅱa 期的患者12例，Ⅱb 期患者2例。通过2个疗程的紫衫醇联合卡铂化疗方案静脉化疗之后，对所有患者都进行宫颈癌根治术，观察分析其治疗效果。结果：化疗的总有效率为70.0%(14/20)；Ⅰb2期的总有效率为66.7%(4/6)，Ⅱa 期的总有效率为66.7%(8/12)，Ⅱb 期的总有效率为50.0%(1/2)，三组间比较差异无统计学意义(P>0.05)。鳞癌的有效率为66.7%(8/12)，腺鳞癌的有效率为25.0%(1/4)，腺癌的有效率为50.0%(2/4)，鳞癌和腺鳞癌的疗效比较差异有统计学意义(P<0.05)。结论：紫杉醇联合卡铂化疗，对于局部晚期宫颈癌的治疗有显著的效果，且有很好的耐受性，值得临床推广。
　　목적：관찰국부만기궁경암신보조화료적림상치료효과。방법：선취필자소재의원2010-2012년수치적국부만기궁경암환자20례，기중Ⅰb2기적환자6례，Ⅱa 기적환자12례，Ⅱb 기환자2례。통과2개료정적자삼순연합잡박화료방안정맥화료지후，대소유환자도진행궁경암근치술，관찰분석기치료효과。결과：화료적총유효솔위70.0%(14/20)；Ⅰb2기적총유효솔위66.7%(4/6)，Ⅱa 기적총유효솔위66.7%(8/12)，Ⅱb 기적총유효솔위50.0%(1/2)，삼조간비교차이무통계학의의(P>0.05)。린암적유효솔위66.7%(8/12)，선린암적유효솔위25.0%(1/4)，선암적유효솔위50.0%(2/4)，린암화선린암적료효비교차이유통계학의의(P<0.05)。결론：자삼순연합잡박화료，대우국부만기궁경암적치료유현저적효과，차유흔호적내수성，치득림상추엄。
Objective:To observe the clinical effects of new adjuvant chemotherapy on locally advanced carcinoma of the cervix.Methods:Select the author’s hospital in 2010-2012 treated 20 patients with locally advanced cervical cancer,including Ⅰb2 period 6 cases,Ⅱa period 12 cases,Ⅱb period 2 cases. Through two course of purple shirts alcohol plus carboplatin chemotherapy regimens after intravenous chemotherapy,for all patients with cervical cancer radical,observation analysis of the therapeutic effect.Results:Chemotherapy,the total effective rate was 70.0%(14/20);Ⅰb2 phase of the total effective rate was 66.7%(4/6),Ⅱa period of the total effective rate was 66.7%(8/12),Ⅱb of the total effective rate was 50.0%(1/2),the difference among three groups had no statistical significance(P>0.05). Squamous cell carcinomas of the effective rate was 66.7%(8/12),effective rate was 25.0%(1/4) of gland scale cancer,gland cancer the effective rate was 50.0%(2/4),squamous carcinoma and the curative effect of gland scale cancer comparative difference was statistically significant(P<0.05). Conclusion:paclitaxel plus carboplatin chemotherapy for locally advanced cervical cancer treatment has a significant effect,and have very good tolerance,worth clinical promotion.