中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2013年
19期
6-7
,共2页
米非司酮%米索前列醇%蜕膜组织%转化生长因子
米非司酮%米索前列醇%蛻膜組織%轉化生長因子
미비사동%미색전렬순%세막조직%전화생장인자
Mifepristone%Misoprostol%Decidual tissue%Transforming growth factor beta
目的：通过研究米非司酮配伍米索前列醇对早孕蜕膜组织转化生长因子表达的影响，探讨米非司酮配伍米索前列醇终止早孕的作用机制。方法：收集2010年8月-2011年5月在笔者所在医院终止妊娠的健康早孕妇女蜕膜组织41例，分为药流组21例和人流组20例，检测蜕膜组织中转化生长因子的表达水平。结果：药流组转化生长因子表达较低，与人流组比较，差异有统计学意义(P<0.05)。结论：米非司酮可以降低早孕蜕膜组织 TGF-β的表达，通过免疫效应达到终止妊娠的目的，米索前列醇增强或独立发挥了终止妊娠的效果。
目的：通過研究米非司酮配伍米索前列醇對早孕蛻膜組織轉化生長因子錶達的影響，探討米非司酮配伍米索前列醇終止早孕的作用機製。方法：收集2010年8月-2011年5月在筆者所在醫院終止妊娠的健康早孕婦女蛻膜組織41例，分為藥流組21例和人流組20例，檢測蛻膜組織中轉化生長因子的錶達水平。結果：藥流組轉化生長因子錶達較低，與人流組比較，差異有統計學意義(P<0.05)。結論：米非司酮可以降低早孕蛻膜組織 TGF-β的錶達，通過免疫效應達到終止妊娠的目的，米索前列醇增彊或獨立髮揮瞭終止妊娠的效果。
목적：통과연구미비사동배오미색전렬순대조잉세막조직전화생장인자표체적영향，탐토미비사동배오미색전렬순종지조잉적작용궤제。방법：수집2010년8월-2011년5월재필자소재의원종지임신적건강조잉부녀세막조직41례，분위약류조21례화인류조20례，검측세막조직중전화생장인자적표체수평。결과：약류조전화생장인자표체교저，여인류조비교，차이유통계학의의(P<0.05)。결론：미비사동가이강저조잉세막조직 TGF-β적표체，통과면역효응체도종지임신적목적，미색전렬순증강혹독립발휘료종지임신적효과。
Objective:Through the research of mifepristone compatibility misoprostol therapy influenced the expression of transforming growth factor beta in early pregnancies decidual tissue,to discuss the function mechanism of termination of the early pregnancy therapy by mifepristone compatibility misoprostol. Methods:41 cases early pregnancy decidual tissue were collected from August 2010 to May 2011 in our hospital women outpatients,21 cases were divided into drug-abortion group,20 cases were divided into abortion group,then detected the expression of transforming growth factor beta.Results:The expression of drug-abortion group had statistically significant with abortion group(P<0.05),drug-abortion group expression was low,and had large difference of expression level. Conclusion:Mifepristone can reduce the expression of transforming growth factor beta,which can terminate pregnancy through the immune effect,misoprostol can enhance the effect or independent play the effect of termination of pregnancy.
