CAJ | 학술논문

　　目的：探讨中药治疗对胰岛素抵抗多囊卵巢综合征(PCOS-IR)患者的临床治疗效果，并测定性激素和胰岛素水平的变化。方法：选择92例 PCOS-IR 患者随机分为观察组和对照组，每组46例。对照组采用二甲双胍药物治疗，观察组在服用西药的基础上再采用疏肝理气、补肾健脾中药进行治疗，两组均连续治疗4个月。同时检测治疗前后两组血清性激素和胰岛素水平的变化，对两组的临床治疗效果、并发症和不良反应情况进行比较分析。结果：两组患者经治疗后，血清黄体生成素(LH)、睾酮(T)、空腹胰岛素(F-INS)的水平较治疗前均有很大程度下降，差异有统计学意义(P 均<0.01)；观察组 LH、T 及 F-INS 下降水平较对照组略大，但差异无统计学意义(P>0.05)；两组患者血清 FSH\FBG 水平比较，差异无统计学意义(P>0.05)。观察组总有效率明显高于对照组，差异有统计学意义(P<0.05)；两组患者在治疗过程中均未出现比较严重的并发症和不良反应现象。结论：采用中西药联合应用对治疗 PCOS-IR 患者治疗效果明显，可降低血清 LH、T、F-INS 水平，提高胰岛素敏感性，改善临床症状，提高排卵率和妊娠率，具有治疗彻底、无特殊的并发症和不良反应特点，可作为对 PCOS-IR 患者治疗的首选方法。
　　목적：탐토중약치료대이도소저항다낭란소종합정(PCOS-IR)환자적림상치료효과，병측정성격소화이도소수평적변화。방법：선택92례 PCOS-IR 환자수궤분위관찰조화대조조，매조46례。대조조채용이갑쌍고약물치료，관찰조재복용서약적기출상재채용소간리기、보신건비중약진행치료，량조균련속치료4개월。동시검측치료전후량조혈청성격소화이도소수평적변화，대량조적림상치료효과、병발증화불량반응정황진행비교분석。결과：량조환자경치료후，혈청황체생성소(LH)、고동(T)、공복이도소(F-INS)적수평교치료전균유흔대정도하강，차이유통계학의의(P 균<0.01)；관찰조 LH、T 급 F-INS 하강수평교대조조략대，단차이무통계학의의(P>0.05)；량조환자혈청 FSH\FBG 수평비교，차이무통계학의의(P>0.05)。관찰조총유효솔명현고우대조조，차이유통계학의의(P<0.05)；량조환자재치료과정중균미출현비교엄중적병발증화불량반응현상。결론：채용중서약연합응용대치료 PCOS-IR 환자치료효과명현，가강저혈청 LH、T、F-INS 수평，제고이도소민감성，개선림상증상，제고배란솔화임신솔，구유치료철저、무특수적병발증화불량반응특점，가작위대 PCOS-IR 환자치료적수선방법。
Objective:To study traditional Chinese medicine treatment for insulin resistance polycystic ovary syndrome(PCOS-IR) patients clinical treatment effect and the determination of hormones and insulin level of change.Methods:A total of 92 patients with PCOS-IR were randomly divided into observation group and control group,each group of each 46 cases.The comparison group used the metformin drug therapy,the observation group took western medicine again on the basis of the kidney and liver,spleen qi of traditional Chinese medicine treatment;Two groups were treated for 4 months. At the same time testing the two groups before and after treatment serum sex hormones and insulin levels and changes of two groups of patients in clinical outcomes,complications and adverse reaction of comparative analysis.Results:Two groups of patients after treatment,serum luteinizing hormone(LH), testosterone(T),fasting insulin(F-INS) level was before treatment greatly decreased significant difference(P<0.01);The observation group LH,T and F-INS down level was slightly larger group,but there was no significant difference(P>0.05);Two groups of patients serum FSH/FBG level were no significant difference(P>0.05).Clinical effects of patients with compared to control group,the efficient was obviously higher than those in the control group,the difference was statistically significance(P<0.05);Two groups of patients in the treatment process all did not appear serious complications and adverse reaction phenomenon.Conclusion:The combined traditional Chinese and western pharmaceutical application in the treatment of PCOS patients by obvious effect,can reduce serum LH,T,F -INS,increase the level of insulin sensitivity,improve clinical symptoms,improve the ovulation rate and pregnancy rate.Therapeutic thoroughly,no special complications of disease and adverse reaction characteristics,can be used as in PCOS patients by the preferred method of treatment.