中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
20期
111-112,113
,共3页
二甲双胍%瑞格列奈%2 型糖尿病
二甲雙胍%瑞格列奈%2 型糖尿病
이갑쌍고%서격렬내%2 형당뇨병
Metformin%Repaglinide%Type 2 diabetes
目的：观察分析二甲双胍联用瑞格列奈对老年2型糖尿病患者的临床效果。方法：选择本院96例老年2型糖尿病患者作为研究对象，随机分成三组，每组32例，所有患者在接受治疗期间同时给予饮食控制和运动治疗，Ⅰ组患者单独口服瑞格列奈片，Ⅱ组患者单独服用盐酸二甲双胍片，Ⅲ组患者则选择联合治疗，即二甲双胍联合瑞格列奈，疗程均为60 d，比较治疗前后对各组血糖、糖化血红蛋白指标，观察用药过程中的不良反应。结果：检测结果显示三组用药后的空腹血糖、餐后2 h 血糖以及糖化血红蛋白均低于治疗前（P<0.05）。Ⅲ组空腹血糖及糖化血红蛋白水平明显低于I、Ⅱ组（P<0.05），餐后2 h 血糖明显低于Ⅱ组（P<0.05）。三组不良反应比较差异均无统计学意义（P>0.05）。结论：二甲双胍联合瑞格列奈治疗糖尿病的效果明显，无严重不良反应，适合老年糖尿病患者的治疗。
目的：觀察分析二甲雙胍聯用瑞格列奈對老年2型糖尿病患者的臨床效果。方法：選擇本院96例老年2型糖尿病患者作為研究對象，隨機分成三組，每組32例，所有患者在接受治療期間同時給予飲食控製和運動治療，Ⅰ組患者單獨口服瑞格列奈片，Ⅱ組患者單獨服用鹽痠二甲雙胍片，Ⅲ組患者則選擇聯閤治療，即二甲雙胍聯閤瑞格列奈，療程均為60 d，比較治療前後對各組血糖、糖化血紅蛋白指標，觀察用藥過程中的不良反應。結果：檢測結果顯示三組用藥後的空腹血糖、餐後2 h 血糖以及糖化血紅蛋白均低于治療前（P<0.05）。Ⅲ組空腹血糖及糖化血紅蛋白水平明顯低于I、Ⅱ組（P<0.05），餐後2 h 血糖明顯低于Ⅱ組（P<0.05）。三組不良反應比較差異均無統計學意義（P>0.05）。結論：二甲雙胍聯閤瑞格列奈治療糖尿病的效果明顯，無嚴重不良反應，適閤老年糖尿病患者的治療。
목적：관찰분석이갑쌍고련용서격렬내대노년2형당뇨병환자적림상효과。방법：선택본원96례노년2형당뇨병환자작위연구대상，수궤분성삼조，매조32례，소유환자재접수치료기간동시급여음식공제화운동치료，Ⅰ조환자단독구복서격렬내편，Ⅱ조환자단독복용염산이갑쌍고편，Ⅲ조환자칙선택연합치료，즉이갑쌍고연합서격렬내，료정균위60 d，비교치료전후대각조혈당、당화혈홍단백지표，관찰용약과정중적불량반응。결과：검측결과현시삼조용약후적공복혈당、찬후2 h 혈당이급당화혈홍단백균저우치료전（P<0.05）。Ⅲ조공복혈당급당화혈홍단백수평명현저우I、Ⅱ조（P<0.05），찬후2 h 혈당명현저우Ⅱ조（P<0.05）。삼조불량반응비교차이균무통계학의의（P>0.05）。결론：이갑쌍고연합서격렬내치료당뇨병적효과명현，무엄중불량반응，괄합노년당뇨병환자적치료。
Objective:To study clinical effects of metformin with repaglinide in elderly patients with type 2 diabetes. Method:Selected 96 cases of elderly patients with type 2 diabetes in our hospital as the research object,they were randomly divided into three groups,each group was 32 cases, and all patients were given diet and exercise therapies at the same time during treatment. Ⅰ group of patients took repaglinide alone,Ⅱ group of patients took metformin hydrochloride alone,and Ⅲ group of patients choosed metformin combined with repaglinide,and all groups were a course of 60 days,and compared blood sugar,glycosylated hemoglobin before and after treatment in each group to observe drug adverse reactions in the process of using drug. Result:Test results showed after medication three groups of empty stomach blood sugar,2 h postprandial blood glucose and glycosylated hemoglobin were lower than before treatment(P<0.05). Ⅲ group of empty stomach blood sugarr and glycated hemoglobin level were significantly lower than that in group I,Ⅱ(P<0.05),and 2 h postprandial blood glucose was significantly lower than Ⅱ group(P<0.05).Compared with adverse reactions of three groups, there was no statistical significance(P>0.05). Conclusion:Metformin and repaglinide treat diabetes have an obviously effect with no serious adverse reactions,and is suitable for the treatment of elderly patients with diabetes.
