中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
20期
90-91,92
,共3页
郑志凌%李卓洪%黄维本%蔡旗
鄭誌凌%李卓洪%黃維本%蔡旂
정지릉%리탁홍%황유본%채기
妊娠期糖尿病%新生儿%心脏功能
妊娠期糖尿病%新生兒%心髒功能
임신기당뇨병%신생인%심장공능
Gestational diabetes mellitus%Newborn%Cardiac function
目的:探讨母亲妊娠期糖尿病(GDM)对所生新生儿的心脏功能的影响,加强对 GDM 母亲所生新生儿的认识及管理,预防病情加重。方法:选取2011年1月-2012年10月本科收治的 GDM 母亲所生新生儿42例作为观察组(GDM 组),选取同期出生的母亲无妊娠期糖尿病,出生无窒息的新生儿42例作为对照组。检测两组的血清血糖、心脏室间隔厚度、左室后壁厚度、射血分数及肌酸激酶(CK)、肌酸激酶同工酶(CKMB)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、羟丁酸脱氢酶(HBDH)的水平。结果:GDM 组与对照组的心肌酶CK、CKMB、AST、LDH、HBDH 的水平比较差异均有统计学意义(P<0.01);GDM 组室间隔厚度、左室后壁厚度在收缩期、舒张期均较对照组增大,差异均有统计学意义(P<0.01),两组左室射血分数比较差异无统计学意义(P>0.05)。结论:GDM 可引起围产儿心脏功能损害;心脏超声检查及血清心肌酶检测可作为早期诊断 GDM 母亲新生儿心脏损害的实验室指标,并可早期诊断和治疗。
目的:探討母親妊娠期糖尿病(GDM)對所生新生兒的心髒功能的影響,加彊對 GDM 母親所生新生兒的認識及管理,預防病情加重。方法:選取2011年1月-2012年10月本科收治的 GDM 母親所生新生兒42例作為觀察組(GDM 組),選取同期齣生的母親無妊娠期糖尿病,齣生無窒息的新生兒42例作為對照組。檢測兩組的血清血糖、心髒室間隔厚度、左室後壁厚度、射血分數及肌痠激酶(CK)、肌痠激酶同工酶(CKMB)、穀草轉氨酶(AST)、乳痠脫氫酶(LDH)、羥丁痠脫氫酶(HBDH)的水平。結果:GDM 組與對照組的心肌酶CK、CKMB、AST、LDH、HBDH 的水平比較差異均有統計學意義(P<0.01);GDM 組室間隔厚度、左室後壁厚度在收縮期、舒張期均較對照組增大,差異均有統計學意義(P<0.01),兩組左室射血分數比較差異無統計學意義(P>0.05)。結論:GDM 可引起圍產兒心髒功能損害;心髒超聲檢查及血清心肌酶檢測可作為早期診斷 GDM 母親新生兒心髒損害的實驗室指標,併可早期診斷和治療。
목적:탐토모친임신기당뇨병(GDM)대소생신생인적심장공능적영향,가강대 GDM 모친소생신생인적인식급관리,예방병정가중。방법:선취2011년1월-2012년10월본과수치적 GDM 모친소생신생인42례작위관찰조(GDM 조),선취동기출생적모친무임신기당뇨병,출생무질식적신생인42례작위대조조。검측량조적혈청혈당、심장실간격후도、좌실후벽후도、사혈분수급기산격매(CK)、기산격매동공매(CKMB)、곡초전안매(AST)、유산탈경매(LDH)、간정산탈경매(HBDH)적수평。결과:GDM 조여대조조적심기매CK、CKMB、AST、LDH、HBDH 적수평비교차이균유통계학의의(P<0.01);GDM 조실간격후도、좌실후벽후도재수축기、서장기균교대조조증대,차이균유통계학의의(P<0.01),량조좌실사혈분수비교차이무통계학의의(P>0.05)。결론:GDM 가인기위산인심장공능손해;심장초성검사급혈청심기매검측가작위조기진단 GDM 모친신생인심장손해적실험실지표,병가조기진단화치료。
Objective:To investigate the effect of gestation diabetes mellitus(GDM)on neonatal cardiac function,strengthen the understanding and management of neonates whose mother have suffered from GDM.Method:42 cases of newborns were selected into the observation group,whose mother have suffered from GDM and treated in our department from January 2011 to October 2012,and other 42 cases of newborns who born in the same period were selected into the control group,whose mother don’t have suffered from GDM.Detected and compared the two sets of newborns’ interventricular septum thickness,left ventricular posterior wall thickness,ejection fraction and the levels of creatine kinase(CK),creatine kinase-MB(CKMB), glutamic-oxaloacetic transaminase(AST),lactate dehydrogenass(LDH),hydroxybutyrate dehydrogenase(HBDH)in the blood.Result:There was significant difference in the myocardial enzymes CK,CKMB,AST,LDH,HBDH between the GDM groups and the control group.The difference was statistically significant(P<0.01).The interventricular septum thickness and the left ventricular posterior wall thickness in the GDM group were increased than the control group.The difference was statistically significant(P<0.01).But the differences in left ventricular ejection fraction between the two sets have no statistical significance(P>0.05).Conclusion:GDM may Cause damage to the perinatal cardiac function.The cardiac ultrasound and the detection of serum myocardial enzyme can be used as laboratory indicators for diagnosing the cardiac damage of GDM’s newborns.