CAJ | 학술논문

目的：探讨埃杜升营养液对高脂血症动物模型血脂水平的影响.方法：通过高脂血症动物模型的建立方法,将小鼠随机分为空白对照组、模型组、阳性对照组及低、中、高剂量组,每组10只.观察小鼠的血脂变化来而探讨埃杜升营养液对高脂血症大鼠模型降低血脂作用的影响.结果：血清甘油三酯(TG)含量随着埃杜升营养液剂量的增加而呈减少的趋势,其中高剂量组明显低于其它各实验组(P<0.01).血清总胆固醇(TC)含量随着埃杜升营养液剂量的增加而减少,其中高剂量组与中、低剂量、阴性对照组和正常对照组比较含量明显下降(P<0.01),而阴性对照组高于其他各组 P<0.01.高密度脂蛋白胆固醇(HDL–C)含量高剂量组高于其他各组,差异有显著性(P<0.01).低密度脂蛋白胆固醇(LDL-C)指标,埃杜升营养液高、中、低剂量组之间无显著差异(P>0.05),阳性对照组略低于埃杜升营养液各剂量组(P>0.05),阳性对照组明显低于阴性对照组(P<0.01)和正常对照组(P<0.05)；阴性对照组明显高于其他各组,差异有显著性(P<0.01).结论：埃杜升营养液对高脂血症大鼠有显著的降低血清 TC、TG、LDL-C,升高 HDL-C 的作用.
목적：탐토애두승영양액대고지혈증동물모형혈지수평적영향.방법：통과고지혈증동물모형적건립방법,장소서수궤분위공백대조조、모형조、양성대조조급저、중、고제량조,매조10지.관찰소서적혈지변화래이탐토애두승영양액대고지혈증대서모형강저혈지작용적영향.결과：혈청감유삼지(TG)함량수착애두승영양액제량적증가이정감소적추세,기중고제량조명현저우기타각실험조(P<0.01).혈청총담고순(TC)함량수착애두승영양액제량적증가이감소,기중고제량조여중、저제량、음성대조조화정상대조조비교함량명현하강(P<0.01),이음성대조조고우기타각조 P<0.01.고밀도지단백담고순(HDL–C)함량고제량조고우기타각조,차이유현저성(P<0.01).저밀도지단백담고순(LDL-C)지표,애두승영양액고、중、저제량조지간무현저차이(P>0.05),양성대조조략저우애두승영양액각제량조(P>0.05),양성대조조명현저우음성대조조(P<0.01)화정상대조조(P<0.05)；음성대조조명현고우기타각조,차이유현저성(P<0.01).결론：애두승영양액대고지혈증대서유현저적강저혈청 TC、TG、LDL-C,승고 HDL-C 적작용.
Objective:To study Aldos nutrient medium on reducing blood lipid in Hyperlipidemia-rat-model. Methods:The Hyperlipidemia model was evaluated after 2 weeks according to blood lipid level. After the Hyperlipidemia-rat-model was established successfully, one group of the model groups was used as negative control group. The subjects in negative control group were fed as usual and the rest 4 groups were fed separately. Three groups of the model were treated respectively with the dosage of 2.5ml/100g (high dose-group), 1.5 ml/100g (medium dose-group) and 0.5ml/100g (low dose- group) of Aldos nutrient medium twice a day. The other was used as positive control group and the subjects were given Simvastatin Tablets 0.265mg/100g. All the subjects of the five model groups were treated continuously for 35 days. To evaluate the establishment of the Hyperlipidemia-rat-model, the serum triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL), low density lipoprotein(LDL) were measured in the middle and at the end of the treatment respectively. Results:The serum TG and TC decreased significantly after the intake ofAldos nutrient medium in different dose groups (P<0.01).The higher the dose, the lower the serum TG and TC. It was shown that the TG and TC in serum in the normal control group were higher than all the other model groups (P<0.01); The serum HDL in high dose-group was higher than other groups(P<0.01), serum LDL in the negative control group increased significantly(P<0.01). Conclusion:The role of Aldos nutrient medium on decreasing serum TG,TC,LDL and increasing serum HDL was significant, which provided strong evidence for the future research of Aldos nutrition medium on strengthening body immune system and preventing certain diseases.