CAJ | 학술논문

目的：观察对奥卡西平（OXC ）治疗部分性癫痫患者的临床疗效及其对脑电活动的影响。方法选取60例部分性癫痫患者为研究对象，应用OXC单药治疗，对治疗第1、第6和第12个月时的临床疗效和对脑电活动的影响进行观察和分析。结果治疗1个月后，SPS、CPS、PS-GTCS等3种发作类型的临床有效率分别88.9％、86.7％和88.8％，差异均无统计学意义（ P＞0.05）；治疗第1、6、12个月临床有效率分别为88.3％、85％和83.3％，差异无统计学意义（ P＞0.05）；治疗第6个月和第12个月时，IEA情况均较治疗前显著改善，治疗第6个月，IEA 消失或减少50％为32例（53.3％）；治疗第12个月， IEA消失或减少50％为35例（58.3％），2个时间段IEA情况比较差异无统计学意义（P＞0.05）；治疗第6个月患者的α波均值和δ波数与治疗前比较无显著性差异（P＞0.05），而θ波数显著高于治疗前（P＜0.05）；治疗第6个月时δ、α和β频段相对功率与治疗前比较差异均无统计学意义（P＞0.05），而θ频段相对功率与治疗前比较显著升高（P＜0.05）。本组出现药物不良反应20％，反应程度均较轻，可自行减轻或消失，未见其他严重不良反应。结论 OXC治疗部分性癫痫发作疗效确切，安全性较高，对患者的脑电活动的影响作用较小，值得临床推广应用。
목적：관찰대오잡서평（OXC ）치료부분성전간환자적림상료효급기대뇌전활동적영향。방법선취60례부분성전간환자위연구대상，응용OXC단약치료，대치료제1、제6화제12개월시적림상료효화대뇌전활동적영향진행관찰화분석。결과치료1개월후，SPS、CPS、PS-GTCS등3충발작류형적림상유효솔분별88.9％、86.7％화88.8％，차이균무통계학의의（ P＞0.05）；치료제1、6、12개월림상유효솔분별위88.3％、85％화83.3％，차이무통계학의의（ P＞0.05）；치료제6개월화제12개월시，IEA정황균교치료전현저개선，치료제6개월，IEA 소실혹감소50％위32례（53.3％）；치료제12개월， IEA소실혹감소50％위35례（58.3％），2개시간단IEA정황비교차이무통계학의의（P＞0.05）；치료제6개월환자적α파균치화δ파수여치료전비교무현저성차이（P＞0.05），이θ파수현저고우치료전（P＜0.05）；치료제6개월시δ、α화β빈단상대공솔여치료전비교차이균무통계학의의（P＞0.05），이θ빈단상대공솔여치료전비교현저승고（P＜0.05）。본조출현약물불량반응20％，반응정도균교경，가자행감경혹소실，미견기타엄중불량반응。결론 OXC치료부분성전간발작료효학절，안전성교고，대환자적뇌전활동적영향작용교소，치득림상추엄응용。
Objective To observe and analyze the curative effects of oxcarbazepine (OXC) on patients with newly diagnosed partial epilepsy and its effects on the electrical activities of the brain. Methods Sixty adult patients with newly diagnosed par-tial epilepsy were selected as the research objects. OXC single drug was applied to the patients. The clinical curative effects in the first ,sixth and twelfth month of the treatment and the effect on the electrical activities of the brain were observed and ana-lyzed. Results After 1 month of OXC treatment ,the clinical efficiency of the three seizure types of SPS ,CPS ,PS-GTCS were 88.9% ,86.7% and 88.8% ,respectively ,there were no significant differences on the curative effect evaluation results and clin-ical efficiency between the three seizure types (P>0.05). At the 1st ,6th ,12th month of the treatment ,the clinical effective rates were 88.3% ,85% and 83.3% ,respectively. There were no significant differences of the curative effects (P>0.05);At 6th month and 12th month of the treatment ,the IEA of this group patients improved significantly compared with that before treatment. At 6th month of the treatment ,the patients whose IEA disappeared or reduced in 50% were 32 cases ,accounting for 53.3% ;At 12th month of the treatment ,the patients whose IEA disappeared or reduced in 50% were 35 cases ,accounting for 58.3%. Between the two time period ,there was no significant difference of IEA (P>0.05).At 6th month of the treatment , there were no significant difference of αwave mean andδwave number of the patients compared with those before treatment (P>0.05) ,wave number was significantly higher than that before treatment (P<0.05);There were no significant difference ofδ,αandβbands relative power compared with those before the treatment (P>0.05) ,and the relative power of θband increased significantly compared with those before treatment (P<0.05). In this group ,the proportion of the patients with drug adverse reactions was 20%. The degrees of the reactions were lighter and were self-relieved or disappeared. No other serious adverse reactions were observed. Conclusion The efficacy of OXC in treatment of newly diagnosed partial epilepsy is sure and certain , which has high security and little effects on the EEG background of the patients ,and is worthy of clinical application.