中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
5期
72-73
,共2页
黄芩苷%耐甲氧西林金黄色葡萄球菌%糖肽类药物
黃芩苷%耐甲氧西林金黃色葡萄毬菌%糖肽類藥物
황금감%내갑양서림금황색포도구균%당태류약물
baicalin%MRSA%glycopeptide
目的：研究黄芩苷对耐甲氧西林金黄色葡萄球菌(MRSA)的抗菌作用，分析其与糖肽类药物体外协同作用。方法：采用微量肉汤稀释法检测黄芩苷对MRSA的最低抑菌浓度( MIC)，用抑菌浓度指数(fractional inhibitory concentration，FIC)评价黄芩苷与糖肽类药物体外协同作用。结果：黄芩苷对MRSA的最低抑菌浓度( MIC)值在128-512μg/ml，与糖肽类药物联合应用对MRSA有协同作用(FIC=0.445)。结论：黄芩苷对MRSA抑菌作用较弱，但黄芩苷与糖肽类药物联合应用对MRSA 有较强的协同作用。
目的：研究黃芩苷對耐甲氧西林金黃色葡萄毬菌(MRSA)的抗菌作用，分析其與糖肽類藥物體外協同作用。方法：採用微量肉湯稀釋法檢測黃芩苷對MRSA的最低抑菌濃度( MIC)，用抑菌濃度指數(fractional inhibitory concentration，FIC)評價黃芩苷與糖肽類藥物體外協同作用。結果：黃芩苷對MRSA的最低抑菌濃度( MIC)值在128-512μg/ml，與糖肽類藥物聯閤應用對MRSA有協同作用(FIC=0.445)。結論：黃芩苷對MRSA抑菌作用較弱，但黃芩苷與糖肽類藥物聯閤應用對MRSA 有較彊的協同作用。
목적：연구황금감대내갑양서림금황색포도구균(MRSA)적항균작용，분석기여당태류약물체외협동작용。방법：채용미량육탕희석법검측황금감대MRSA적최저억균농도( MIC)，용억균농도지수(fractional inhibitory concentration，FIC)평개황금감여당태류약물체외협동작용。결과：황금감대MRSA적최저억균농도( MIC)치재128-512μg/ml，여당태류약물연합응용대MRSA유협동작용(FIC=0.445)。결론：황금감대MRSA억균작용교약，단황금감여당태류약물연합응용대MRSA 유교강적협동작용。
Objective:To study the synergistic effect of baicalin and the glycopeptide against methicil in-resistant staphylococcus aureus(MRSA) . Methods:The MIC were determined by broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration (FIC). Results:We observed baicalin of minimum inhibitory concentrations (MICs) values of 128 to 512μg/ml with the MRSA strains tested. Synergistic activity (FIC≤0.5) was observed for combinations with baicalin /glycopeptidecombination possessed the strongest synergistic(FIC=0.445). Conclusion:Baicalin acts synergistical y with the glycopeptide, enhancing its antimicrobial activity against MRSA.
