CAJ | 학술논문

目的：探讨孕早期妇女弓形虫感染对妊娠结局的影响。方法采用酶联免疫吸附试验检测2993例孕妇外周血中弓形虫IgM和IgG抗体，将感染者分为急性感染组、既往感染组、活动性感染组，并从非感染者中随机抽取200名孕妇作为对照组，对4组进行随访，观察比较4组的妊娠结局。结果共检测出弓形虫感染者286例，总感染率为9.56%（286/2993），其中急性感染43例、既往感染156例、活动性感染87例；以上3组及对照组不良妊娠结局发生率分别为13.95%（6/43）、1.92%（3/156）、5.75%（5/87）和1.50%（3/200）。急性感染组和活动性感染组不良妊娠结局发生率与对照组比较，差异均有统计学意义（P均＜0.05）；既往感染组与对照组比较，差异无统计学意义（P＞0.05）。结论弓形虫急性感染和活动性感染与孕早期妇女不良妊娠结局密切相关，应将弓形虫IgM抗体检测作为育龄妇女孕前常规检查项目。
목적：탐토잉조기부녀궁형충감염대임신결국적영향。방법채용매련면역흡부시험검측2993례잉부외주혈중궁형충IgM화IgG항체，장감염자분위급성감염조、기왕감염조、활동성감염조，병종비감염자중수궤추취200명잉부작위대조조，대4조진행수방，관찰비교4조적임신결국。결과공검측출궁형충감염자286례，총감염솔위9.56%（286/2993），기중급성감염43례、기왕감염156례、활동성감염87례；이상3조급대조조불량임신결국발생솔분별위13.95%（6/43）、1.92%（3/156）、5.75%（5/87）화1.50%（3/200）。급성감염조화활동성감염조불량임신결국발생솔여대조조비교，차이균유통계학의의（P균＜0.05）；기왕감염조여대조조비교，차이무통계학의의（P＞0.05）。결론궁형충급성감염화활동성감염여잉조기부녀불량임신결국밀절상관，응장궁형충IgM항체검측작위육령부녀잉전상규검사항목。
Objective To explore the impact of Toxoplasma gondii infection on pregnancy outcomes in early pregnancy wom-en. Methods Toxoplasma gondii IgM and IgG antibodies in the peripheral blood of 2 993 early pregnant women were detected by using enzyme-linked immunosorbent assay(ELISA). According to the test results,the infected ones were divided into an acute in-fection group,a previous infection group,and an active infection group,and 200 pregnant women without Toxoplasma infection were randomly chosen as a control group,and the pregnancy outcomes of the four groups were followed up and the results were compared. Results There were 286 women infected with Toxoplasma gondii,with the infection rate of 9.56%(286/2 993),in which 43 cases were diagnosed as acute infection,156 were previous cases,and the other 87 were active infection ones. The inci-dences of adverse pregnancy outcomes in the above 3 groups and the control group were 13.95%(6/43),1.92%(3/156),5.75%(5/87)and 1.50%(3/200),respectively. The incidences of adverse pregnancy outcomes in the acute infection group and active in-fection group were both higher than that in the control group,the differences were statistically significant(both P<0.05),while there was no significant difference between the previous infection group and control group(P>0.05). Conclusion Acute and ac-tive Toxoplasma gondii infections are closely associated with the occurrence of adverse pregnancy outcomes in early pregnant wom-en;therefore,Toxoplasma gondii IgM antibody should be included in the routine inspection items of the pre-pregnancy physical examination for child-bearing age women.