CAJ | 학술논문

肿瘤微环境与肿瘤细胞通过分子和细胞间的相互作用，在肿瘤的发生发展和转移扩散中具有重要意义。肿瘤相关巨噬细胞（TAMs）作为肿瘤微环境中数量最多的炎症细胞群之一，在肿瘤进展中起到重要作用。肿瘤细胞通过释放多种趋化因子、细胞因子和生长因子招募巨噬细胞，并使其向M2型巨噬细胞类似的特性发展。同时，巨噬细胞释放多种因子，促进肿瘤细胞的生长、血管新生、迁移、侵袭、侵入血管并最终形成远处转移。TAMs在肿瘤组织中的密度与肿瘤患者治疗失败和不良预后密切相关，以TAMs为靶点的抗肿瘤治疗相关研究近年来取得重大进展。在肿瘤发生发展中根据TAMs的作用机制，以TAMs为靶点的抗肿瘤治疗策略是抑制肿瘤微环境中巨噬细胞招募、TAMs生存能力、TAMs表型即由M2型转化为M1型的重塑。本文就TAMs为靶点的抗肿瘤治疗最新进展进行综述。
종류미배경여종류세포통과분자화세포간적상호작용，재종류적발생발전화전이확산중구유중요의의。종류상관거서세포（TAMs）작위종류미배경중수량최다적염증세포군지일，재종류진전중기도중요작용。종류세포통과석방다충추화인자、세포인자화생장인자초모거서세포，병사기향M2형거서세포유사적특성발전。동시，거서세포석방다충인자，촉진종류세포적생장、혈관신생、천이、침습、침입혈관병최종형성원처전이。TAMs재종류조직중적밀도여종류환자치료실패화불량예후밀절상관，이TAMs위파점적항종류치료상관연구근년래취득중대진전。재종류발생발전중근거TAMs적작용궤제，이TAMs위파점적항종류치료책략시억제종류미배경중거서세포초모、TAMs생존능력、TAMs표형즉유M2형전화위M1형적중소。본문취TAMs위파점적항종류치료최신진전진행종술。
Tumor cells and the tumor microenvironment interact through molecular and cellular mechanisms to promote tumorigenesis and tumor migration. The tumor microenvironment is important in tumorigenesis and tumor progression. Tumor-associated macrophages (TAMs), which are ones of the most inflammatory cells in the tumor microenvironment, have significant influence on tumor development. Tumor cells recruit macrophages by releasing chemokines, cytokines, and growth factors, and switch them into M2-type macrophages. Macrophages also release many factors which are important to some stages of tumor development, including tumor growth, angiogenesis, migration, invasion, and distant metastasis. TAM density is associated with treatment failure and poor prognosis in tumor patients. Great progress has recently been made in targeting TAMs for anti-tumor therapy. Strategies of targeting TAMs for anti-tumor therapy include suppression of macrophage recruitment, inhibition of TAM viability, reinstating the TAM phenotype, and transforming M2-type macrophages to M1-type macrophages. This article reviews the latest progress in the field based on TAM functions.