CAJ | 학술논문

目的：用白芨提取物及消炎止痛的药用成分制成双层口腔贴膜。方法：白芨葡甘聚糖胶加入消炎止痛药物摊涂成药膜，在药膜上涂以PVA、CMC-Na等高分子材料做成的保护膜，制成双层贴膜。结果：制成的膜剂具有良好的粘性和柔韧性，体外释放成线性，在口腔中的溶解时间长，具有缓释效果。通过对26例口腔溃疡病人的临床疗效观察，其总有效率为93%。可以显著促进溃疡面愈合，缓解疼痛。结论：以白芨凝胶为主要材料，辅以几种药用成分制成的药膜具有去腐生肌，消炎止痛的功效，而且缓释效果明显，具有良好的推广前景。
목적：용백급제취물급소염지통적약용성분제성쌍층구강첩막。방법：백급포감취당효가입소염지통약물탄도성약막，재약막상도이PVA、CMC-Na등고분자재료주성적보호막，제성쌍층첩막。결과：제성적막제구유량호적점성화유인성，체외석방성선성，재구강중적용해시간장，구유완석효과。통과대26례구강궤양병인적림상료효관찰，기총유효솔위93%。가이현저촉진궤양면유합，완해동통。결론：이백급응효위주요재료，보이궤충약용성분제성적약막구유거부생기，소염지통적공효，이차완석효과명현，구유량호적추엄전경。
Objective: Baiji extract and anti-inflammatory ingredients were made for double-oral film. Methods: Glucomannan white glue and anti-inflammatory medication were made to form membrane, the membrane coated with PVA, CMC-Na, etc. made of polymer materials, made of double film. Results:Film formers good results of the viscosity and flexibility, in vitro releasing is linear, long dissolution time in the oral cavity, having a sustained releasing effect. Through clinical observation, 26 oral ulcer patients, the overall efficacy was 98%. Conclusion:Baiji gel as the main material, membrane supported by several pharmaceutical ingredients made with Qufu Shengji, anti-inflammatory and analgesic effects, and slow-release effect is obvious.