CAJ | 학술논문

目的：探讨圣愈汤加味联合大分割放射改善骨转移癌患者的生存质量，提高治疗有效率的优势及安全性。方法：将骨转移癌患者90例随机分为3组，综合治疗组[圣愈汤加味联合大分割放疗（3000 cGy/10次，1次/d，5次/周）]、大分割组、常规分割组，于4周后观察3组患者疗效及毒副反应。结果：综合治疗组、大分割组、常规分割组对骨转移癌痛缓解有效率分别为84.38%、82.14%、80.00%，3组比较差异无统计学意义（P＞0.05），在中医证候明显改善率、生活质量提高率方面综合治疗组明显优于大分割组及常规分割组（P＜0.05）。结论：圣愈汤加味联合大分割放疗治疗骨转移癌疗效确切，能明显提高患者生存质量。
목적：탐토골유탕가미연합대분할방사개선골전이암환자적생존질량，제고치료유효솔적우세급안전성。방법：장골전이암환자90례수궤분위3조，종합치료조[골유탕가미연합대분할방료（3000 cGy/10차，1차/d，5차/주）]、대분할조、상규분할조，우4주후관찰3조환자료효급독부반응。결과：종합치료조、대분할조、상규분할조대골전이암통완해유효솔분별위84.38%、82.14%、80.00%，3조비교차이무통계학의의（P＞0.05），재중의증후명현개선솔、생활질량제고솔방면종합치료조명현우우대분할조급상규분할조（P＜0.05）。결론：골유탕가미연합대분할방료치료골전이암료효학절，능명현제고환자생존질량。
Objective: To investigate the advantages of improving life quality and treatment effective rates and the safety of modifiedShengYudecoction and hyperfraction radiotherapy in treating metastatic carcinoma of bone. Methods: Ninety patients were randomized into three groups: comprehensive treatment group[modifiedShengYude-coction and hyperfraction radiotherapy (3 000 cGy each ten times, once per day, each week five times)], hyperfrac-tion radtiontherapy group and convention fraction group. Toxicity and curative effects of three groups were observed after treating for 4 weeks. Results: Pain remission effective rates of metastatic carcinoma of bone in comprehensive treatment group, hyperfraction radiotherapy group and convention fraction group were 84.38%, 82.14% and 80.00% respectively, the differences demonstrated no statistical meaning among three groups(P>0.05), comprehensive treat-ment group was remarkably superior to hyperfraction radiotherapy group and convention fraction group in improve-ment rates of TCM symptom and life quality (P<0.05). Conclusion: ModifiedShengYudecoction and hyperfraction radiotherapy could obtain definite effects in treating metastatic carcinoma of bone, and the therapy could improve life quality of the patients obviously.