CAJ | 학술논문

目的：研究表明有氧运动可缓解乳腺癌患者因化疗引起的癌因性疲乏（ CRF），但仍有部分研究存在争议性结论，本研究旨在探讨有氧运动对乳腺癌化疗患者 CRF 的干预疗效。方法计算机检索 Pubmed、Embase、CISCOM、CINAHL、谷歌学术、CBM 和中国知网等中英文数据库。检索范围从建库至2013-09-01，采用 STATA 12.0软件进行 Meta 分析，计算标准均方差（SMD）及其95％可信区间（95％ CI）评价两者关联性。结果本研究共计纳入了12项病例对照研究共1014例乳腺癌化疗患者，其中包括522例有氧运动患者（试验组）和492例对照患者（对照组）。Meta 分析的结果表明：试验组的 Piper 疲乏量表（ RPFS）评分低于对照组，差异有统计学意义〔 SMD ＝-0.82，95％ CI（-1.04，-0.60），P ﹤0.001〕；然而，癌症治疗功能评估疲乏量表（FACIT - F）评分在两组间差异无统计学意义〔SMD ＝0.09，95％ CI（-0.07，0.25），P ＝0.224〕。根据不同种族进行亚组分析发现，两组 RPFS 和FACIT - F 评分在亚洲人群中差异有统计学意义〔 RPFS：SMD ＝-1.08，95％ CI（-1.35，-0.82），P ﹤0.001；FACIT - F：SMD ＝1.20，95％ CI（0.70，1.71），P ﹤0.001〕，但是在欧美人群中差异无统计学意义（P ﹥0.05）。结论有氧运动可以有效改善乳腺癌患者化疗引起的CRF，尤其在亚洲人群中表现更为明显。
목적：연구표명유양운동가완해유선암환자인화료인기적암인성피핍（ CRF），단잉유부분연구존재쟁의성결론，본연구지재탐토유양운동대유선암화료환자 CRF 적간예료효。방법계산궤검색 Pubmed、Embase、CISCOM、CINAHL、곡가학술、CBM 화중국지망등중영문수거고。검색범위종건고지2013-09-01，채용 STATA 12.0연건진행 Meta 분석，계산표준균방차（SMD）급기95％가신구간（95％ CI）평개량자관련성。결과본연구공계납입료12항병례대조연구공1014례유선암화료환자，기중포괄522례유양운동환자（시험조）화492례대조환자（대조조）。Meta 분석적결과표명：시험조적 Piper 피핍량표（ RPFS）평분저우대조조，차이유통계학의의〔 SMD ＝-0.82，95％ CI（-1.04，-0.60），P ﹤0.001〕；연이，암증치료공능평고피핍량표（FACIT - F）평분재량조간차이무통계학의의〔SMD ＝0.09，95％ CI（-0.07，0.25），P ＝0.224〕。근거불동충족진행아조분석발현，량조 RPFS 화FACIT - F 평분재아주인군중차이유통계학의의〔 RPFS：SMD ＝-1.08，95％ CI（-1.35，-0.82），P ﹤0.001；FACIT - F：SMD ＝1.20，95％ CI（0.70，1.71），P ﹤0.001〕，단시재구미인군중차이무통계학의의（P ﹥0.05）。결론유양운동가이유효개선유선암환자화료인기적CRF，우기재아주인군중표현경위명현。
Objective Studies show that aerobic exercise may receive cancer - related fatigue of breast cancer patients undergoing chemotherapy,but some with controversial results. This meta - analysis is aimed to explore the intervention effects of aerobic exercise on CRF in breast cancer patients receiving chemotherapy. Methods A literature search of PubMed,Embase, CISCOM,CINAHL,Google Scholar,CNKI and CBM databases was conducted on articles published before September 1st, 2013. STATA 12. 0 software was used for the meta - analysis. Crude standardized mean difference(SMD)and its 95% confidence interval(CI)were calculated,and according to the results the association of the two was assessed. Results Twelve cases were brought into the comparative studies with a total of 1 014 breast cancer patients receiving chemotherapy,including 522 patients in the aerobic exercise group(the intervention group)and 492 patients in the usual care group(the control group). The meta - a-nalysis results revealed that the RPFS scores of breast cancer patients in the intervention group were significantly lower than those in the control group〔SMD = - 0. 82,95% CI( - 1. 04, - 0. 60),P ﹤ 0. 001〕. However,there was no significant difference in FACIT - F scores between the intervention and control groups〔SMD = 0. 09,95% CI( - 0. 07,0. 25),P = 0. 224〕. Sub-group analysis by ethnicity indicated that there were significant differences in RPFS and FACIT - F scores between the intervention and control groups among Asian populations〔RPFS:SMD = - 1. 08,95% CI( - 1. 35, - 0. 82),P ﹤ 0. 001;FACIT - F:SMD = 1. 20,95% CI(0. 70,1. 71),P ﹤ 0. 001〕,but no significance among Caucasian populations(P ﹥ 0. 05). Conclu-sion The current meta - analysis indicates that aerobic exercise may improve cancer - related fatigue in breast cancer patients re-ceiving chemotherapy,especially among Asian populations.