中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
15期
1728-1730,1738
,共4页
李元成%崔志丹%沈伶
李元成%崔誌丹%瀋伶
리원성%최지단%침령
子宫肌瘤%胰岛素样生长因子Ⅰ%胰岛素样生长因子Ⅱ%雌激素受体%孕激素受体
子宮肌瘤%胰島素樣生長因子Ⅰ%胰島素樣生長因子Ⅱ%雌激素受體%孕激素受體
자궁기류%이도소양생장인자Ⅰ%이도소양생장인자Ⅱ%자격소수체%잉격소수체
Uterine leiomyoma%Insulin - like growth factor Ⅰ%Insulin - like growth factor Ⅱ%Estrogen receptor%Progestrone receptor
目的：探讨子宫肌瘤患者外周血胰岛素样生长因子（IGF）-Ⅰ和 IGF -Ⅱ水平的变化及其与子宫肌瘤组织雌激素受体（ER）、孕激素受体（PR）的关系。方法选择2013年1-9月在汕头大学医学院第一附属医院妇产科住院手术治疗临床诊断为子宫肌瘤的患者56例为研究组，另选择同期在本院进行健康体检的45例健康女性为对照组。采用酶联免疫吸附试验法测定研究组及对照组外周血 IGF -Ⅰ、IGF -Ⅱ水平，采用免疫组化方法测定研究组子宫肌瘤组织 ER 和 PR 的表达情况，分析子宫肌瘤患者外周血 IGF -Ⅰ、IGF -Ⅱ水平与子宫肌瘤组织中 ER、PR 表达的相关性。结果研究组外周血 IGF -Ⅰ和 IGF -Ⅱ水平均高于对照组（P <0.05）。子宫肌瘤患者 ER（＋）组外周血IGF -Ⅰ和 IGF -Ⅱ水平均高于 ER（-）组（P <0.05）；子宫肌瘤患者 PR（＋）组外周血 IGF -Ⅰ和 IGF -Ⅱ水平均高于 PR（-）组（P <0.05）。相关性分析结果显示，子宫肌瘤患者外周血 IGF -Ⅰ和 IGF -Ⅱ水平与子宫肌瘤组织中ER、PR 表达评分均呈正相关（P <0.05）。结论子宫肌瘤的发生和发展可能与患者外周血 IGF -Ⅰ和 IGF -Ⅱ水平升高有关，并且与子宫肌瘤 ER、PR 的表达相关。
目的：探討子宮肌瘤患者外週血胰島素樣生長因子（IGF）-Ⅰ和 IGF -Ⅱ水平的變化及其與子宮肌瘤組織雌激素受體（ER）、孕激素受體（PR）的關繫。方法選擇2013年1-9月在汕頭大學醫學院第一附屬醫院婦產科住院手術治療臨床診斷為子宮肌瘤的患者56例為研究組，另選擇同期在本院進行健康體檢的45例健康女性為對照組。採用酶聯免疫吸附試驗法測定研究組及對照組外週血 IGF -Ⅰ、IGF -Ⅱ水平，採用免疫組化方法測定研究組子宮肌瘤組織 ER 和 PR 的錶達情況，分析子宮肌瘤患者外週血 IGF -Ⅰ、IGF -Ⅱ水平與子宮肌瘤組織中 ER、PR 錶達的相關性。結果研究組外週血 IGF -Ⅰ和 IGF -Ⅱ水平均高于對照組（P <0.05）。子宮肌瘤患者 ER（＋）組外週血IGF -Ⅰ和 IGF -Ⅱ水平均高于 ER（-）組（P <0.05）；子宮肌瘤患者 PR（＋）組外週血 IGF -Ⅰ和 IGF -Ⅱ水平均高于 PR（-）組（P <0.05）。相關性分析結果顯示，子宮肌瘤患者外週血 IGF -Ⅰ和 IGF -Ⅱ水平與子宮肌瘤組織中ER、PR 錶達評分均呈正相關（P <0.05）。結論子宮肌瘤的髮生和髮展可能與患者外週血 IGF -Ⅰ和 IGF -Ⅱ水平升高有關，併且與子宮肌瘤 ER、PR 的錶達相關。
목적：탐토자궁기류환자외주혈이도소양생장인자（IGF）-Ⅰ화 IGF -Ⅱ수평적변화급기여자궁기류조직자격소수체（ER）、잉격소수체（PR）적관계。방법선택2013년1-9월재산두대학의학원제일부속의원부산과주원수술치료림상진단위자궁기류적환자56례위연구조，령선택동기재본원진행건강체검적45례건강녀성위대조조。채용매련면역흡부시험법측정연구조급대조조외주혈 IGF -Ⅰ、IGF -Ⅱ수평，채용면역조화방법측정연구조자궁기류조직 ER 화 PR 적표체정황，분석자궁기류환자외주혈 IGF -Ⅰ、IGF -Ⅱ수평여자궁기류조직중 ER、PR 표체적상관성。결과연구조외주혈 IGF -Ⅰ화 IGF -Ⅱ수평균고우대조조（P <0.05）。자궁기류환자 ER（＋）조외주혈IGF -Ⅰ화 IGF -Ⅱ수평균고우 ER（-）조（P <0.05）；자궁기류환자 PR（＋）조외주혈 IGF -Ⅰ화 IGF -Ⅱ수평균고우 PR（-）조（P <0.05）。상관성분석결과현시，자궁기류환자외주혈 IGF -Ⅰ화 IGF -Ⅱ수평여자궁기류조직중ER、PR 표체평분균정정상관（P <0.05）。결론자궁기류적발생화발전가능여환자외주혈 IGF -Ⅰ화 IGF -Ⅱ수평승고유관，병차여자궁기류 ER、PR 적표체상관。
Objective To study the changes of insulin - like growth factor(IGF) - Ⅰ and IGF - Ⅱ in peripheral blood of patients with uterine leiomyoma and its relation with estrogen receptor(ER)and progestrone receptor(PR)in uterine leiomyoma tissues. Methods 56 patients diagnosed as leiomyoma in the department ofgynecology of the First Affiliated Hospital of Shantou University Medical College from January to September in 2013 were selected as the study group,while 45 healthy women having physical examination over the same period were selected as control group. The levels of IGF - Ⅰ and IGF - Ⅱ in peripheral blood in patients with uterine leiomyoma were determined by enzyme linked immunosorbent assay,and the expression of ER and PR in uterine leiomyoma tissues were determined by immunohistochemistry methods. The relation between the levels of IGF - Ⅰand IGF - Ⅱ and the expression of ER and PR in uterine leiomyoma tissues was analyzed. Results The levels of IGF - Ⅰ and IGF - Ⅱ in the study group were significantly higher than the control group(P < 0. 05). The levels of IGF - Ⅰ and IGF - Ⅱ in ER( + )patients were significantly higher than the ER( - )patients(P < 0. 05). The levels of IGF - Ⅰ and IGF - Ⅱ in PR ( + )patients were significantly higher than the PR( - )patients(P < 0. 05). Correlation analysis showed that the levels of IGF - Ⅰ and IGF - Ⅱ in patients with uterine leiomyoma were positively correlated with ER and PR(P < 0. 05). Conclusion The occurrence and development of uterine leiomyoma are probably related with the levels of IGF - Ⅰ and IGF - Ⅱ in the periph-eral blood of patients,and are also related with the expression of ER and PR.
