CAJ | 학술논문

　　背景：研究表明针灸结合中药治疗膝骨关节炎具有一定的效果。目的：探讨针灸结合中药治疗膝骨关节炎的机制及效果评价。方法：建立膝骨关节炎动物模型，检测相关因子基质金属蛋白酶3、转化生长因子β、白细胞介素1β和肿瘤坏死因子α表达含量的变化；对应用针灸联合药物治疗膝骨关节炎的患者进行随访观察，针刺主穴结合配穴，中药服用或外敷熏蒸，观察膝关节活动功能恢复情况，明确应用针灸结合中药干预治疗的效果。结果与结论：针灸治疗能够通过降低基质金属蛋白酶3、转化生长因子β、白细胞介素1β和肿瘤坏死因子α的含量，延缓膝关节软骨的破坏，改善膝关节功能，从而发挥对膝骨性关节炎的治疗作用。膝骨关节炎的患者应用针灸结合中药治疗后，获得较好的效果，治疗有效率高达90%以上，并且与单一应用透明质酸钠或针灸治疗相比较，针灸结合中药治疗的有效率更高，治疗效果更好。
　　배경：연구표명침구결합중약치료슬골관절염구유일정적효과。목적：탐토침구결합중약치료슬골관절염적궤제급효과평개。방법：건립슬골관절염동물모형，검측상관인자기질금속단백매3、전화생장인자β、백세포개소1β화종류배사인자α표체함량적변화；대응용침구연합약물치료슬골관절염적환자진행수방관찰，침자주혈결합배혈，중약복용혹외부훈증，관찰슬관절활동공능회복정황，명학응용침구결합중약간예치료적효과。결과여결론：침구치료능구통과강저기질금속단백매3、전화생장인자β、백세포개소1β화종류배사인자α적함량，연완슬관절연골적파배，개선슬관절공능，종이발휘대슬골성관절염적치료작용。슬골관절염적환자응용침구결합중약치료후，획득교호적효과，치료유효솔고체90%이상，병차여단일응용투명질산납혹침구치료상비교，침구결합중약치료적유효솔경고，치료효과경호。
BACKGROUND: Studies have shown that acupuncture combined with Chinese medicine has a certain effect in the treatment of knee osteoarthritis. OBJECTIVE: To investigate the mechanism and effect of acupuncture combined with Chinese medicine for the treatment of knee osteoarthritis. METHODS: The animal models of knee osteoarthritis were established to detect the expression levels of related factors, including matrix metal oproteinase 3, transforming growth factor β, interleukin-1β and tumor necrosis factor-α. The knee osteoarthritis patients treated with acupuncture combined with Chinese medicine were fol owed-up, and the patients received acupuncture in the main points and the adjunct points, as wel as the Chinese medicine administration and the external application and fumigation. Then, the active function recovery of the knee joint was observed to identify the effect of acupuncture combined with Chinese medicine. RESUTLS AND CONCLUSION: Acupuncture can delay the destruction of knee joint articular cartilage and improve the knee function through decreasing the contents of matrix metal oproteinase 3, transforming growth factor β, interleukin-1β and tumor necrosis factor-α, thus playing the treatment effect on knee osteoarthritis. The knee osteoarthritis patients treated with acupuncture combined with Chinese medicine can obtain better effect, and the treatment efficiency is more than 90%. Compared with the single application of sodium hyaluronate or acupuncture treatment, acupuncture combined with Chinese medicine has higher treatment efficiency and better treatment effect.