CAJ | 학술논문

　　背景：前期研究已经发现，2型糖尿病的易感基因脂联素基因、钙蛋白酶10基因等与中国肾移植患者移植后糖尿病的发生显著相关。猜测其他2型糖尿病的易感基因是否也与移植后糖尿病相关。目的：分析锌转运蛋白-8(SLC30A8)基因多态性与移植后糖尿病的相关性。方法：采用实时荧光定量PCR法检测97例移植后糖尿病患者和301例未发生移植后糖尿病的肾移植患者(对照组)的SLC30A8 rs13266634的基因型，采用 logistic 回归分析该基因多态性与移植后糖尿病的相关性。结果与结论：移植后糖尿病组和对照组患者 rs13266634的等位基因频率和基因型分布差异具有显著性意义(P <0.05)。用性别、移植时年龄、体质量和体质量指数等危险因素进行校正后，CC基因型患者肾移植后发生移植后糖尿病的风险是TT基因型患者的2.108倍(OR=2.108，95%CI：1.075-4.131，P=0.044)；CC+CT基因型患者肾移植后发生移植后糖尿病的风险是TT基因型患者的1.862倍(OR=1.862，95%CI：1.049-3.306， P=0.034)。提示SLC30A8基因rs13266634的C等位基因是肾移植后发生移植后糖尿病的独立危险因素。
　　배경：전기연구이경발현，2형당뇨병적역감기인지련소기인、개단백매10기인등여중국신이식환자이식후당뇨병적발생현저상관。시측기타2형당뇨병적역감기인시부야여이식후당뇨병상관。목적：분석자전운단백-8(SLC30A8)기인다태성여이식후당뇨병적상관성。방법：채용실시형광정량PCR법검측97례이식후당뇨병환자화301례미발생이식후당뇨병적신이식환자(대조조)적SLC30A8 rs13266634적기인형，채용 logistic 회귀분석해기인다태성여이식후당뇨병적상관성。결과여결론：이식후당뇨병조화대조조환자 rs13266634적등위기인빈솔화기인형분포차이구유현저성의의(P <0.05)。용성별、이식시년령、체질량화체질량지수등위험인소진행교정후，CC기인형환자신이식후발생이식후당뇨병적풍험시TT기인형환자적2.108배(OR=2.108，95%CI：1.075-4.131，P=0.044)；CC+CT기인형환자신이식후발생이식후당뇨병적풍험시TT기인형환자적1.862배(OR=1.862，95%CI：1.049-3.306， P=0.034)。제시SLC30A8기인rs13266634적C등위기인시신이식후발생이식후당뇨병적독립위험인소。
BACKGROUND:Previous studies have found that the susceptibility genes of adiponectin gene and calpain 10 gene of type 2 diabetes are closely related with the incidence of diabetes in Chinese renal transplantation patients. So, are other susceptibility genes of type 2 diabetes also associated with posttransplantation diabetes mel itus? OBJECTIVE:To investigate the association between the zinc transporter solute carrier family 30 member 8 (SLC30A8) gene polymorphism and the posttransplantation diabetes mel itus. METHODS:A total of 97 patients with posttransplantation diabetes mel itus and 301 patents without posttransplantation diabetes mel itus (control group) were selected, and then the SLC30A8 gene rs13266634 genotype was detected with real-time PCR method. The association between gene polymorphism and posttransplantation diabetes mel itus was analyzed with Logistic regression test. RESULTS AND CONCLUSION:There were significant differences in al ele frequencies and genotype distributions of rs13266634 between the patients with and without posttransplantation diabetes mel itus (P<0.05). After adjustments of age, sex, body weight and body mass index, the incidence of posttransplantation diabetes mel itus of the CC genotype patients was 2.108 times to that of the TT genotype patients (odds ratio=2.108, 95%confidence interval:1.075-4.131, P=0.044);and the incidence of posttransplantation diabetes mel itus of the CC+CT genotype patients was 1.862 times to that of the TT genotype patients (odds ratio=1.862, 95%confidence interval:1.049-3.306, P=0.034). The results suggest that the C-al ele in rs13266634 of SLC30A8 gene is the independent risk factor of posttransplantation diabetes mel itus.