CAJ | 학술논문

　　目的通过研究乳猪腮腺放射治疗前后弥散加权成像的变化，探讨弥散加权成像对乳猪腮腺放射性损伤的诊断价值。方法12只乳猪分成两组，对照组4只，放疗组8只。放疗组乳猪经麻醉后实施单剂量放疗。所有乳猪均行MR常规检查和弥散加权成像检查。测量各组乳猪腮腺的ADC值，记录放疗前后腮腺组织的改变情况。结果放疗前，对照组以及放疗组左、右侧乳猪腮腺唾液流率的差异无统计学意义（P跃0.05），对照组和放疗组的ADC值之间差异无统计学意义（P跃0.05）。放疗后，对照组乳猪的腮腺唾液流率稍有升高，而放疗组乳猪的腮腺唾液流率以及相应的ADC值均有不同程度的降低，放疗组左、右侧及对照组乳猪腮腺唾液流率的差异均有统计学意义（P约0.05）。结论 ADC值可一定程度地反映腮腺放疗后组织内微观结构的改变，弥散加权成像可为监测乳猪腮腺放射性损伤提供一种方法。
　　목적통과연구유저시선방사치료전후미산가권성상적변화，탐토미산가권성상대유저시선방사성손상적진단개치。방법12지유저분성량조，대조조4지，방료조8지。방료조유저경마취후실시단제량방료。소유유저균행MR상규검사화미산가권성상검사。측량각조유저시선적ADC치，기록방료전후시선조직적개변정황。결과방료전，대조조이급방료조좌、우측유저시선타액류솔적차이무통계학의의（P약0.05），대조조화방료조적ADC치지간차이무통계학의의（P약0.05）。방료후，대조조유저적시선타액류솔초유승고，이방료조유저적시선타액류솔이급상응적ADC치균유불동정도적강저，방료조좌、우측급대조조유저시선타액류솔적차이균유통계학의의（P약0.05）。결론 ADC치가일정정도지반영시선방료후조직내미관결구적개변，미산가권성상가위감측유저시선방사성손상제공일충방법。
Objective To evaluate the diagnostic value of diffusion weighted imaging (DWI)for assessing radiation damage to parotid glands of miniature pigs. Methods Miniature pigs were exposed to single-dose radiation on either the left or right parotid gland(n=8)or they were not exposed to radiation(n=4),then all pigs were examined by conventional magnetic resonance imaging and DWI.Pathological changes and ADC values for parotid glands were recorded before and after irradiation. Results Before irradiation, the three groups did not differ significantly in salivary flow rate or ADC value(P>0.05).The flow rate increased slightly in the control group over the course of the study,and both flow rate and ADC value were significantly lower in the irradiated groups than in the control group (P<0.05).In addition,the two groups irradiated on the left or right parotid differed significantly in flow rate and ADC value(P<0.05). Conclusions The ADC value may indicate microstructural changes in parotid gland tissue after irradiation,and DWI may prove a useful method for monitoring parotid gland radiosensitivity.