CAJ | 학술논문

　　目的探讨多药耐药基因-1（multidrug resistance gene 1，MDR1）基因C1236T rs 1128503位点多态性与广西肝癌发生的关系。方法采用病例-对照研究方法，从广西肝癌高发区人群中选择109例肝癌患者及109名健康对照者，采用基质辅助激光解吸附电离飞行时间质谱技术（MALDI-TOF-MS）检测MDR1基因C1236T rs 1128503位点的基因型及等位基因频率。结果 MDR1基因C1236T rs 1128503位点的CC基因型、CT基因型、TT基因型在病例组与对照组间的分布频率差异均无统计学意义（P>0.05）。等位基因C和T在两组中的分布频率分别为42.20%和57.80%，两组间分布频率的差异无统计学意义（P>0.05）。结论MDR1基因C1236T rs 1128503位点的CT或TT基因型携带者的肝癌发病风险未见显著增加，MDR1基因多态性可能不是广西肝癌发生的遗传易感因素。
　　목적탐토다약내약기인-1（multidrug resistance gene 1，MDR1）기인C1236T rs 1128503위점다태성여엄서간암발생적관계。방법채용병례-대조연구방법，종엄서간암고발구인군중선택109례간암환자급109명건강대조자，채용기질보조격광해흡부전리비행시간질보기술（MALDI-TOF-MS）검측MDR1기인C1236T rs 1128503위점적기인형급등위기인빈솔。결과 MDR1기인C1236T rs 1128503위점적CC기인형、CT기인형、TT기인형재병례조여대조조간적분포빈솔차이균무통계학의의（P>0.05）。등위기인C화T재량조중적분포빈솔분별위42.20%화57.80%，량조간분포빈솔적차이무통계학의의（P>0.05）。결론MDR1기인C1236T rs 1128503위점적CT혹TT기인형휴대자적간암발병풍험미견현저증가，MDR1기인다태성가능불시엄서간암발생적유전역감인소。
Objective To evaluate the correlation between the C1236T rs 1128503 polymorphism in the multidrug resistance 1 (MDR1)gene and primary liver cancer (PLC)in a Guangxi Zhuang population. Methods A case-control study of 109 PLC patients and 109 healthy controls was conducted in a Guangxi area with a high PLC incidence.Genotypes and alleles of MDR1 C1236T rs 1128503 were detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS). Results The PLC and control group did not differ significantly in frequencies of MDR1 rs 1128503 CC,CT,or TT genotypes,or in frequencies of C and T alleles(P>0.05).The frequencies of C and T alleles were 42.20% and 57.80%. Conclusions Risk of PLC is not increased in carriers of the MDR1 C1236T rs 1128503 CT or TT genotypes.MDR1 polymorphism may not be a genetic susceptibility factor for PLC.