CAJ | 학술논문

　　目的探讨高压性脾静脉与曲张大隐静脉管壁中膜胶原和弹力纤维的变化，评估静脉管壁胶原和弹力纤维重塑程度。方法收集门脉高压症脾静脉和曲张大隐静脉管壁标本各20例，另设脾外伤正常脾静脉和正常大隐静脉管壁标本作对照组各20例。行 EVG 染色，光镜下观察管壁胶原和弹力纤维分布,测定胶原纤维相对含量（RCC）和弹力纤维相对含量（RCE）。结果脾静脉组RCC、RCE 分别为（50.75±14.79）%、（11.36±4.03）%，对照组为（31.22±5.71）%、（14.60±2.95）%， RCC、RCE 比较差异均有统计学意义（RCC：P <0.01；RCE：P <0.05）；曲张组分别为（29.71±6.63）%、（7.50±2.49）%，对照组为（23.52±6.20）%、（9.71±3.89）%，RCC 比较差异有统计学意义（P <0.05）。脾静脉组 RCC 变化比率与曲张组比较有显著性差异（P <0.01）。结论静脉高压状态下脾静脉和大隐静脉管壁中膜胶原纤维含量明显增多、弹力纤维减少，且脾静脉胶原纤维增多比率比大隐静脉更明显。
　　목적탐토고압성비정맥여곡장대은정맥관벽중막효원화탄력섬유적변화，평고정맥관벽효원화탄력섬유중소정도。방법수집문맥고압증비정맥화곡장대은정맥관벽표본각20례，령설비외상정상비정맥화정상대은정맥관벽표본작대조조각20례。행 EVG 염색，광경하관찰관벽효원화탄력섬유분포,측정효원섬유상대함량（RCC）화탄력섬유상대함량（RCE）。결과비정맥조RCC、RCE 분별위（50.75±14.79）%、（11.36±4.03）%，대조조위（31.22±5.71）%、（14.60±2.95）%， RCC、RCE 비교차이균유통계학의의（RCC：P <0.01；RCE：P <0.05）；곡장조분별위（29.71±6.63）%、（7.50±2.49）%，대조조위（23.52±6.20）%、（9.71±3.89）%，RCC 비교차이유통계학의의（P <0.05）。비정맥조 RCC 변화비솔여곡장조비교유현저성차이（P <0.01）。결론정맥고압상태하비정맥화대은정맥관벽중막효원섬유함량명현증다、탄력섬유감소，차비정맥효원섬유증다비솔비대은정맥경명현。
Objective To investigate the changes of collagen and elastic fibers in hypertensive splenic vein and varicose great saphenous vein wall media, in order to compare the degree of collagen and elastic fiber remodeling in the two kinds of veins. Methods Four groups were divided, including Splenic veins of patients with portal hypertension (n=20) and control group (n=20), varicose great saphenous veins (n=20) and control group (n=20) were collected and stained with elastica van Gieson (EVG), the distribution of collagen and elastic fibers in vein walls was observed, and the relative content of collagen (RCC). The relative content of elastic fibers (RCE) were measured with light microscope. Results RCC and RCE were (50.75±14.79)% and (11.36±4.03)%in splenic vein group, (31.22±5.71)% and (14.60±2.95)% in control group, respectively. For RCC and RCE, there were significant differences between the splenic vein group and control group (RCC: P < 0.01 , RCE:P < 0.05). RCC and RCE were (29.71±6.63)% and (7.50±2.49)% in varicose group, (23.52 ± 6.20)% and (9.71 ± 3.89)% in control group, respectively. The difference of RCC was statistically significant (P < 0.05). For change ratio of RCC, there were statistically significant differences between the splenic vein groups and varicose group (P < 0.01). Conclusion Collagen fiber content increased significantly and elastic fibers reduced in splenic vein and great saphenous vein wall media under the state of venous hypertension. And the ratio of increase in splenic veins is significantly more than that in great saphenous veins.