CAJ | 학술논문

　　目的探讨以苦豆子油搽剂为主的阶梯式治疗方案与传统治疗方案治疗慢性湿疹皮炎的疗效及安全性。方法试验组给予苦豆子油搽剂2次/d为基础治疗，对照组采用曲安奈德搽剂2次/d为基础治疗。试验组中病情轻度的患者采用基础治疗；病情中度的患者除给予基础治疗外，配合氯雷他定片早1片、酮替芬片睡前1片口服；病情重度的患者在使用病情中度患者的治疗基础上，尚加用曲安奈德搽剂2次/d外用治疗。对照组病情轻度者给予基础治疗；病情中度者在基础治疗的基础上，配合氯雷他定片早1片、酮替芬片睡前1片口服；病情重度者在使用病情中度缓和的治疗基础上，尚加用泼尼松2片，3次/d（服用5 d）。治疗疗程为2周。结果共入组患者270例，两方案相应治疗组年龄、性别及病情严重程度无显著差异。各组疗效两两比较，试验组与对照组比较均无显著性差异。安全性而言，对照组各组不良反应发生率高于方案1各组不良反应。结论以苦豆子油搽剂为主的阶梯式治疗方案治疗慢性湿疹皮炎安全有效。
　　목적탐토이고두자유차제위주적계제식치료방안여전통치료방안치료만성습진피염적료효급안전성。방법시험조급여고두자유차제2차/d위기출치료，대조조채용곡안내덕차제2차/d위기출치료。시험조중병정경도적환자채용기출치료；병정중도적환자제급여기출치료외，배합록뢰타정편조1편、동체분편수전1편구복；병정중도적환자재사용병정중도환자적치료기출상，상가용곡안내덕차제2차/d외용치료。대조조병정경도자급여기출치료；병정중도자재기출치료적기출상，배합록뢰타정편조1편、동체분편수전1편구복；병정중도자재사용병정중도완화적치료기출상，상가용발니송2편，3차/d（복용5 d）。치료료정위2주。결과공입조환자270례，량방안상응치료조년령、성별급병정엄중정도무현저차이。각조료효량량비교，시험조여대조조비교균무현저성차이。안전성이언，대조조각조불량반응발생솔고우방안1각조불량반응。결론이고두자유차제위주적계제식치료방안치료만성습진피염안전유효。
Objective We aimed to evaluate the efficacy and safety of two step treatment programs in treating patients of PLA with chronic dermatitis and eczema. Methods Outpatients of PLA with chronic eczema and dermatitis in our department were divided into two groups (treatment group and control group) randomly according to EISA scores. The patients of the treatment group with mild condition were given only empyreumatic oil from sophora alopecuroides L (EOSA), and the control group given triamcinolone acetonide liniment. The patients of the treatment group with moderate condition were given EOSA; the control group given triamcinolone acetonide liniment;both of the two groups were also given one loratadine tablets in the morning and ketotifen tablets before sleep. The patients of the treatment group with severe condition were given EOSA and given one Loratadine tablets in the morning and ketotifen tablets before sleep and also given triamcinolone acetonide liniment while the patients of the control group were given triamcinolone acetonide liniment, and given one loratadine tablets in the morning and ketotifen tablets before sleep and also given two prednisone tablets three times a day for five days. The course covered two weeks. Results There were no significant difference in therapeutic effects of two groups after one or two weeks’duration. The patients in the control group had higher incidence of adverse effects than those in treatment group. Conclusion Step Treatment Program, of which EOSA was the main subject, was more effective and safe for treatment of the patients with chronic eczema and dermatitis.