CAJ | 학술논문

　　目的了解抗菌药物对耐甲氧西林金黄色葡萄球菌（MRSA）引起的下呼吸道医院感染的治疗效果，并比较万古霉素与替考拉宁的疗效差异。方法对64例MRSA所致医院获得性下呼吸道感染病例进行回顾性分析，并采用病例对照研究方法比较34例万古霉素治疗患者和30例替考拉宁治疗患者的疗效。结果使用万古霉素和替考拉宁治疗的共计64例患者有效率为70.3%，万古霉素组的疗程、有效率和MRSA清除率分别为11.1 d、65.6%和61.8%，替考拉宁组分别为12.1 d、76.7%和70.0%，两组比较均无统计学差异。结论万古霉素、和替考拉宁胺都可用于治疗MRSA引起的下呼吸道医院感染且治疗效果无差异。
　　목적료해항균약물대내갑양서림금황색포도구균（MRSA）인기적하호흡도의원감염적치료효과，병비교만고매소여체고랍저적료효차이。방법대64례MRSA소치의원획득성하호흡도감염병례진행회고성분석，병채용병례대조연구방법비교34례만고매소치료환자화30례체고랍저치료환자적료효。결과사용만고매소화체고랍저치료적공계64례환자유효솔위70.3%，만고매소조적료정、유효솔화MRSA청제솔분별위11.1 d、65.6%화61.8%，체고랍저조분별위12.1 d、76.7%화70.0%，량조비교균무통계학차이。결론만고매소、화체고랍저알도가용우치료MRSA인기적하호흡도의원감염차치료효과무차이。
Objective We aimed to investigate the therapeutic effect of antimicrobial agents for lower respiratory tract nosocomical infections caused by Methicillin-resistant Staphylococcus aureus(MRSA),and compare the clinical effects between vancomycin and teicoplanin.Methods All 64 cases of lower respiratory tract nosocomical infections caused by MRSA who were treated in our hospital were analyzed retrospectively. The differences of the clinical effects of 34 cases with vancomycin therapy and 30 cases with teicoplanin were compared. Results The effective rate of all 64 cases treated with vancomycin,teicoplanin and linezolid was 70.3%. The length of stay,effective rate and MRSA clearance rate between vancomycin group and teicoplanin group had no statistically significance, with 11.1 days ,65.6% and 61.8% in the former,12.1 days, 76.7% and 70.0% in the latter.Conclusions Vancomycin, teicoplanin and linezolid could be used to treat lower respiratory tract infection caused by MRSA.Both vancomycin and teicoplanin exhibited a similar clinical efficacy.