湖南师范大学学报(医学版)
湖南師範大學學報(醫學版)
호남사범대학학보(의학판)
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2013年
2期
45-48
,共4页
张明星%王建生%王文涛%谢贞波%张振楚%王杰%许浪
張明星%王建生%王文濤%謝貞波%張振楚%王傑%許浪
장명성%왕건생%왕문도%사정파%장진초%왕걸%허랑
非小细胞肺癌%STKl5%基因多态性
非小細胞肺癌%STKl5%基因多態性
비소세포폐암%STKl5%기인다태성
non-small cell lung carcinoma%STKl5%polymorphism
目的:探讨丝氨酸苏氨酸激酶15 T基因(STK15)多态性和非小细胞肺癌(NSCLC)发生的关系。方法:采用病例对照研究方法,以聚合酶链反应限制性片段长度多态性(PCR-RFLP)技术,检测275例非小细胞肺癌患者和500例正常对照者STKl5 Phe31 Ile基因型,比较不同基因型与非小细胞肺癌危险性及其病理特征的关系。结果:STKl5 Phe31 Ile三种基因型(Phe/Phe、Phe/Ile、Ile/Ile)在病例组的分布频率分别为21.4%、24.6%和54.0%,在对照组分别为25.6%、39.7%和34.7%,分布差异具有统计学意义。携带STKl5 Ile/Ile基因型者患非小细胞肺癌癌的风险比携带STKl5 Phe/Phe基因型者增加174%(OR=2.67,95%CI=1.143~6.593),此种风险增加在吸烟患者中更为显著(OR=5.429,95%CI=1.478~24.542)。未发现STKl5 Phe31 Ile基因多态与非小细胞肺癌病理特征相关。结论:STKl5 Phe31 Ile基因多态可能是非小细胞肺癌的遗传易感因素。
目的:探討絲氨痠囌氨痠激酶15 T基因(STK15)多態性和非小細胞肺癌(NSCLC)髮生的關繫。方法:採用病例對照研究方法,以聚閤酶鏈反應限製性片段長度多態性(PCR-RFLP)技術,檢測275例非小細胞肺癌患者和500例正常對照者STKl5 Phe31 Ile基因型,比較不同基因型與非小細胞肺癌危險性及其病理特徵的關繫。結果:STKl5 Phe31 Ile三種基因型(Phe/Phe、Phe/Ile、Ile/Ile)在病例組的分佈頻率分彆為21.4%、24.6%和54.0%,在對照組分彆為25.6%、39.7%和34.7%,分佈差異具有統計學意義。攜帶STKl5 Ile/Ile基因型者患非小細胞肺癌癌的風險比攜帶STKl5 Phe/Phe基因型者增加174%(OR=2.67,95%CI=1.143~6.593),此種風險增加在吸煙患者中更為顯著(OR=5.429,95%CI=1.478~24.542)。未髮現STKl5 Phe31 Ile基因多態與非小細胞肺癌病理特徵相關。結論:STKl5 Phe31 Ile基因多態可能是非小細胞肺癌的遺傳易感因素。
목적:탐토사안산소안산격매15 T기인(STK15)다태성화비소세포폐암(NSCLC)발생적관계。방법:채용병례대조연구방법,이취합매련반응한제성편단장도다태성(PCR-RFLP)기술,검측275례비소세포폐암환자화500례정상대조자STKl5 Phe31 Ile기인형,비교불동기인형여비소세포폐암위험성급기병리특정적관계。결과:STKl5 Phe31 Ile삼충기인형(Phe/Phe、Phe/Ile、Ile/Ile)재병례조적분포빈솔분별위21.4%、24.6%화54.0%,재대조조분별위25.6%、39.7%화34.7%,분포차이구유통계학의의。휴대STKl5 Ile/Ile기인형자환비소세포폐암암적풍험비휴대STKl5 Phe/Phe기인형자증가174%(OR=2.67,95%CI=1.143~6.593),차충풍험증가재흡연환자중경위현저(OR=5.429,95%CI=1.478~24.542)。미발현STKl5 Phe31 Ile기인다태여비소세포폐암병리특정상관。결론:STKl5 Phe31 Ile기인다태가능시비소세포폐암적유전역감인소。
Objective To elucidate the association between the polymorphism of STKl5 and the risk of Non-Small Cell Lung Carcinoma. Methods In a case-control study,genotypes of STKl5 Phe31Ile were determined by PCR-RLFP in 275 patients with Non-Small Cell Lung Carcinoma and 500 controls. Their association with Non-Small Cell Lung Carcinoma risk and pathological outcome were analyzed. The adjusted odds ratios (ORs) and 95%confidence intervals (CIs) were calculated using logistic regression model. Results The frequency of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of STKl5 Phe31 Ile in Non-Small Cell Lung Carcinoma patients was 21.4%, 24.6% and 54.0% respectively, which was significantly different from that in the controls (25.6%, 39.7% and 34.7%) (P=0.024).Subjects with the Ile/Ile genotype had an increased risk for the occurrence of Non-Small Cell Lung Carcinoma compared with those with the Phe/Phe genotype (OR=5.429, 95%CI=1.478~24.542). The risk was more significant in the subjects who smoked (OR=5.429, 95%CI=1.478~24.542). No significant association was observed between the STKl5 polymorphism and Non-Small Cell Lung Carcinoma pathological outcome. Conclu-sion Our study suggestes that STKl 5 Phe31 Ile polymorphisms are likely to be associated with an increased risk of Non-Small Cell Lung Carcinoma in Chinese people.