CAJ | 학술논문

　　目的：探讨丝氨酸苏氨酸激酶15 T基因(STK15)多态性和非小细胞肺癌(NSCLC)发生的关系。方法：采用病例对照研究方法，以聚合酶链反应限制性片段长度多态性(PCR-RFLP)技术，检测275例非小细胞肺癌患者和500例正常对照者STKl5 Phe31 Ile基因型，比较不同基因型与非小细胞肺癌危险性及其病理特征的关系。结果：STKl5 Phe31 Ile三种基因型(Phe/Phe、Phe/Ile、Ile/Ile)在病例组的分布频率分别为21.4％、24.6％和54.0％，在对照组分别为25.6％、39.7％和34.7％，分布差异具有统计学意义。携带STKl5 Ile/Ile基因型者患非小细胞肺癌癌的风险比携带STKl5 Phe/Phe基因型者增加174％(OR=2.67，95％CI=1.143～6.593)，此种风险增加在吸烟患者中更为显著(OR=5.429，95％CI=1.478～24.542)。未发现STKl5 Phe31 Ile基因多态与非小细胞肺癌病理特征相关。结论：STKl5 Phe31 Ile基因多态可能是非小细胞肺癌的遗传易感因素。
　　목적：탐토사안산소안산격매15 T기인(STK15)다태성화비소세포폐암(NSCLC)발생적관계。방법：채용병례대조연구방법，이취합매련반응한제성편단장도다태성(PCR-RFLP)기술，검측275례비소세포폐암환자화500례정상대조자STKl5 Phe31 Ile기인형，비교불동기인형여비소세포폐암위험성급기병리특정적관계。결과：STKl5 Phe31 Ile삼충기인형(Phe/Phe、Phe/Ile、Ile/Ile)재병례조적분포빈솔분별위21.4％、24.6％화54.0％，재대조조분별위25.6％、39.7％화34.7％，분포차이구유통계학의의。휴대STKl5 Ile/Ile기인형자환비소세포폐암암적풍험비휴대STKl5 Phe/Phe기인형자증가174％(OR=2.67，95％CI=1.143～6.593)，차충풍험증가재흡연환자중경위현저(OR=5.429，95％CI=1.478～24.542)。미발현STKl5 Phe31 Ile기인다태여비소세포폐암병리특정상관。결론：STKl5 Phe31 Ile기인다태가능시비소세포폐암적유전역감인소。
Objective To elucidate the association between the polymorphism of STKl5 and the risk of Non-Small Cell Lung Carcinoma. Methods In a case-control study,genotypes of STKl5 Phe31Ile were determined by PCR-RLFP in 275 patients with Non-Small Cell Lung Carcinoma and 500 controls. Their association with Non-Small Cell Lung Carcinoma risk and pathological outcome were analyzed. The adjusted odds ratios (ORs) and 95%confidence intervals (CIs) were calculated using logistic regression model. Results The frequency of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of STKl5 Phe31 Ile in Non-Small Cell Lung Carcinoma patients was 21.4%, 24.6% and 54.0% respectively, which was significantly different from that in the controls (25.6%, 39.7% and 34.7%) (P=0.024).Subjects with the Ile/Ile genotype had an increased risk for the occurrence of Non-Small Cell Lung Carcinoma compared with those with the Phe/Phe genotype (OR=5.429, 95%CI=1.478~24.542). The risk was more significant in the subjects who smoked (OR=5.429, 95%CI=1.478~24.542). No significant association was observed between the STKl5 polymorphism and Non-Small Cell Lung Carcinoma pathological outcome. Conclu-sion Our study suggestes that STKl 5 Phe31 Ile polymorphisms are likely to be associated with an increased risk of Non-Small Cell Lung Carcinoma in Chinese people.