CAJ | 학술논문

　　目的：观察急性胰腺炎患者血清淀粉样蛋白A(serum amyloid A protein，SAA)、降钙素原（procalci-tonin，PCT）和C反应蛋白（C-reactive protein，CRP）在急性胰腺炎早期病程中的变化，探讨SAA、PCT及CRP在急性胰腺炎其临床实用价值。方法：轻型急性胰腺炎（MAP）患者32例，重症胰腺炎(SAP)患者10例，动态检测入院时和入院后第1、3、5、7天血清SAA、PCT及CRP的水平，并均与42例健康对照组相互比较。结果：（1）急性胰腺炎患者各个不同时间点SAA、PCT及CRP均显著高于对照组。（2）其中CRP在入院后第3天达最高水平，随后逐步降低，第3天后两组差异显著；在MAP组于入院后第3天达峰值，随后显著下降并逐步恢复正常水平，而SPA组一直保持在较高的水平。（3）SAA于SAP组、MAP组均在入院后第1天为最高水平，随后逐步降低，各时间点与第1天比较，差异显著。（4）PCT在SAP组入院后第1天、3天为最高水平，在MAP组第1天为最高水平，随后均逐步降低，各时间点与第1天比较，差异显著。结论：血清SAA、PCT及CRP水平的变化反应了急性胰腺炎患者病情严重程度，其中SAA和PCT对急性胰腺炎早期病程判断具有一定的临床意义。
　　목적：관찰급성이선염환자혈청정분양단백A(serum amyloid A protein，SAA)、강개소원（procalci-tonin，PCT）화C반응단백（C-reactive protein，CRP）재급성이선염조기병정중적변화，탐토SAA、PCT급CRP재급성이선염기림상실용개치。방법：경형급성이선염（MAP）환자32례，중증이선염(SAP)환자10례，동태검측입원시화입원후제1、3、5、7천혈청SAA、PCT급CRP적수평，병균여42례건강대조조상호비교。결과：（1）급성이선염환자각개불동시간점SAA、PCT급CRP균현저고우대조조。（2）기중CRP재입원후제3천체최고수평，수후축보강저，제3천후량조차이현저；재MAP조우입원후제3천체봉치，수후현저하강병축보회복정상수평，이SPA조일직보지재교고적수평。（3）SAA우SAP조、MAP조균재입원후제1천위최고수평，수후축보강저，각시간점여제1천비교，차이현저。（4）PCT재SAP조입원후제1천、3천위최고수평，재MAP조제1천위최고수평，수후균축보강저，각시간점여제1천비교，차이현저。결론：혈청SAA、PCT급CRP수평적변화반응료급성이선염환자병정엄중정도，기중SAA화PCT대급성이선염조기병정판단구유일정적림상의의。
Objective To explore the dynamic changes and value of the serum amyloid A protein, procalci-tonin and C-vreactive protein during the early process of acute pancreatitis. Methods 42 patients were divided into two groups:mild acute pancreatitis (n=32) and severe acute pancreatitis(n=10).All patients were employed for measuring the serum levels of SAA, PCT and CRP in patients on days 1, 3, 5, 7 of onset of acute pancreatitis, 42 health volunteers were enrolled as control group. Results (1) SAA, PCT and CRP levels in patients with acute pancreatitis were significantly higher than those in control group. (2) The levels of CRP of two groups reached the peak in day 3, and there was no difference in 3 days,But there was difference between MAP and SPA group after days 3. (3) the peak serum level of SAA in both SAP and MAP groups occurred on day 1, decreased with the treatment . (4) PCT level reached the peak in day 1 and day 3 for SAP group, day 1 for MAP group respectively, decreased with the treatment as well. Conclusion The changes of serum SAA, PCT and CRP levels manifest posi-tive correlations to the severity of the condition of the patients with acute pancreatitis, serum SAA and PCT level can be more informative than serum CRP level in evaluating the changes of the conditions in early acute pancre-atitis.