CAJ | 학술논문

　　目的：探讨妊娠晚期亚临床甲减及TPO-Ab对妊娠结局的影响。方法：回顾性分析2011年8月至2013年2月湖南省人民院109名孕妇的病历资料。亚临床甲减组（A组）42例，其中TPO-Ab阳性（A1组）6例， TPO-Ab阴性（A2组）36例；正常对照组（B组）67例，其中TPO-Ab阳性（B1组）12例，TPO-Ab阴性（B2组）55例。分析其年龄、心率等一般资料，空腹血糖、甲状腺功能及TPO-Ab等生化指标，评估母亲和胎儿合并症。结果：1.亚临床甲减组平均心率较正常对照组偏低，差异有统计学意义，但两组在其他一般情况、生化指标、孕妇代谢指标及新生儿出生时情况等方面的无明显差异。2.亚临床甲减组较正常对照组胎儿合并症及胎儿窘迫发生风险均增加，差异有统计学意义，但两组母亲合并症没有区别。3.亚临床甲减合并TPO-Ab阳性组与合并TPO-Ab阴性组比较，母亲合并症、胎儿合并症、胎膜早破、胎儿窘迫、早产的发生率均升高，且差异有统计学意义。结论：妊娠晚期亚临床甲减，尤其是合并有TPO-Ab阳性者是妊娠的高危因素，可导致不良妊娠结局发生率增高。
　　목적：탐토임신만기아림상갑감급TPO-Ab대임신결국적영향。방법：회고성분석2011년8월지2013년2월호남성인민원109명잉부적병력자료。아림상갑감조（A조）42례，기중TPO-Ab양성（A1조）6례， TPO-Ab음성（A2조）36례；정상대조조（B조）67례，기중TPO-Ab양성（B1조）12례，TPO-Ab음성（B2조）55례。분석기년령、심솔등일반자료，공복혈당、갑상선공능급TPO-Ab등생화지표，평고모친화태인합병증。결과：1.아림상갑감조평균심솔교정상대조조편저，차이유통계학의의，단량조재기타일반정황、생화지표、잉부대사지표급신생인출생시정황등방면적무명현차이。2.아림상갑감조교정상대조조태인합병증급태인군박발생풍험균증가，차이유통계학의의，단량조모친합병증몰유구별。3.아림상갑감합병TPO-Ab양성조여합병TPO-Ab음성조비교，모친합병증、태인합병증、태막조파、태인군박、조산적발생솔균승고，차차이유통계학의의。결론：임신만기아림상갑감，우기시합병유TPO-Ab양성자시임신적고위인소，가도치불량임신결국발생솔증고。
Objective To observe the effect of late pregnancy subclinical hypothyroidism and TPOAb on pregnancy outcome.Methods Collecting the gravida information of the People's Hospital of Hunan Province from Augest 2011 to February 2013. The case group(A group)has 42 subjects,control group (B group) has 67 subjects. Analyzing the clinical data,thyroid function,TPO-Ab and other biochemical indicators,meanwhile assessing the maternal and fetal complications.Results 1. The average levels of heart rate in A group were slightly slower than those of the control group, and the differences between them had statistical significance.But the differences be-tween A group and B group in other clinical data, biochemical markers had no statistical significance.2. Fetal complications and fetal distress both increased in A group than those of control group,but there were no statisti-cally significant differences in maternal complications.3. Fetal complications, Maternal complications, Premature rupture of membranes, fetal distress and premature all increased in A group than those of control group.Conclu-sion subclinical hypothyroidism and TPO-Ab positive in late pregnancy are high-risk factors of pregnancy.