CAJ | 학술논문

　　在碱性介质中，阿奇霉素对 luminol－KIO4化学发光体系有显著的抑制作用．基于此，提出了一种流动注射化学发光测定阿奇霉素的新方法．对检测条件进行了优化．样品检测速率为109个／h．在优化条件下，阿奇霉素的线性范围为3．0×10－8～9．0×10－6 mol／L，相关系数 r ＝0．994，检出限（RSN ＝3）为1．6×10－8 mol／L．对3．0×10－7 mol ／L 的阿奇霉素溶液进行11次平行测定，其 RSD 为3．8％．将提出的方法成功应用于阿奇霉素胶囊中阿奇霉素含量的测定．
　　재감성개질중，아기매소대 luminol－KIO4화학발광체계유현저적억제작용．기우차，제출료일충류동주사화학발광측정아기매소적신방법．대검측조건진행료우화．양품검측속솔위109개／h．재우화조건하，아기매소적선성범위위3．0×10－8～9．0×10－6 mol／L，상관계수 r ＝0．994，검출한（RSN ＝3）위1．6×10－8 mol／L．대3．0×10－7 mol ／L 적아기매소용액진행11차평행측정，기 RSD 위3．8％．장제출적방법성공응용우아기매소효낭중아기매소함량적측정．
A new and rapid method for determination of azithromycin by flow -injection coupled with chemilumines-cence detection was developed , which based on azithromycin inhibiting effect on chemiluminescence system of luminol -KIO4 in alkaline solution.The running conditions of FI-CL system were investigated.And the sampling detecting rate was about 109 samples /h.Under the optimum conditions, linearity for azithromycin was found in the range of 3.0 × 10 -8 ~9.0 ×10 -6 mol /L with the detection limit (RSN =3) of 1.6 ×10-8 mol/L.The relative standard deviation (RSD)was found to be 3.8 % for 11 replicate determinations of 3.0 ×10 -7 mol/L azithromycin.The proposed meth-od has been applied for the determination of azithromycin in azithromycin capsule .