CAJ | 학술논문

　　目的：探讨毛冬青总提取物抗血栓及对微循环的作用。方法：采用FeCl3诱导大鼠体内血栓模型，结合对小鼠进行胶原蛋白-肾上腺素和角叉菜胶诱发体内血栓实验；观察毛冬青总体物的抗血栓作用，并利用激光多普勒血流仪，测其温控血流变化及RF/PF值。结果：与模型组相比，毛冬青总提取物能显著降低大鼠颈总动脉血栓质量，能使小鼠体内血栓形成的保护率增加、黑尾发生率降低、黑尾相对长度减小，局部微血管热刺激的血流百分变化值增加、压力阻断后反应性充血的RF/PF减小。结论：毛冬青总提取物能抑制体内血栓的形成，改善微循环，保护微循环可能是其作用机制之一。
　　목적：탐토모동청총제취물항혈전급대미순배적작용。방법：채용FeCl3유도대서체내혈전모형，결합대소서진행효원단백-신상선소화각차채효유발체내혈전실험；관찰모동청총체물적항혈전작용，병이용격광다보륵혈류의，측기온공혈류변화급RF/PF치。결과：여모형조상비，모동청총제취물능현저강저대서경총동맥혈전질량，능사소서체내혈전형성적보호솔증가、흑미발생솔강저、흑미상대장도감소，국부미혈관열자격적혈류백분변화치증가、압력조단후반응성충혈적RF/PF감소。결론：모동청총제취물능억제체내혈전적형성，개선미순배，보호미순배가능시기작용궤제지일。
Objective: To explore the effect and mechanism of the extract of Ilex pubescens on thrombosis and microcirculation. Methods: Collagen-adrenaline, FeCl3,and carrageen were used to induce thrombosis models in mouse or rat respectively to observe the to observe the antithrombotic effect of the extract of Ilex pubescens .Doppler flowmetry was used to measure the heat-provoked change of blood flow and RF/PF value of post occlusive reactive hyperemia. Results: Compared with the result of model group, the extract of Ilex pubescens could significantly reduce the rat common carotid artery thrombus,reduce the incidence and relative length of black ened tail, increase the percentage change of blood flow,and decrease RF/PF. Conclusion: The extract of Ilex pubescens can inhibit thrombosis in vivo and improve microcirculation, which may be the mechanism of inhibitory effect of the extract of Iles on thrombosis.