中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
28期
8-9
,共2页
纪玉强%谢梅%刘佩勇%赵朝
紀玉彊%謝梅%劉珮勇%趙朝
기옥강%사매%류패용%조조
心肌炎%肿瘤坏死因子配体相关分子1A%免疫损伤
心肌炎%腫瘤壞死因子配體相關分子1A%免疫損傷
심기염%종류배사인자배체상관분자1A%면역손상
Myocarditis%Tumor necrosis factor ligands related molecule 1A%Immane injury
目的 探讨肿瘤坏死因子配体相关分子1A(TL1A)在病毒性心肌炎患者外周血中的表达水平及临床意义.方法 分别采用酶联免疫吸附试验法和实时定量PCR法检测70例病毒性心肌炎患者(病毒性心肌炎组)及70例健康体检者(对照组)血浆TL1A水平和外周血TL1A mRNA的表达水平.结果 病毒性心肌炎组血浆TL1A水平[(1.37±0.41) μg/L]明显高于对照组[(0.85±0.22)μg/L],差异有统计学意义(P=0.000)；病毒性心肌炎组外周血TL1A mRNA水平(0.39±0.17)明显高于对照组(0.31±0.11),差异有统计学意义(P=0.001).结论 病毒性心肌炎患者外周血TL1A表达水平升高,TL1A可能参与了病毒性心肌炎的发病过程.
目的 探討腫瘤壞死因子配體相關分子1A(TL1A)在病毒性心肌炎患者外週血中的錶達水平及臨床意義.方法 分彆採用酶聯免疫吸附試驗法和實時定量PCR法檢測70例病毒性心肌炎患者(病毒性心肌炎組)及70例健康體檢者(對照組)血漿TL1A水平和外週血TL1A mRNA的錶達水平.結果 病毒性心肌炎組血漿TL1A水平[(1.37±0.41) μg/L]明顯高于對照組[(0.85±0.22)μg/L],差異有統計學意義(P=0.000)；病毒性心肌炎組外週血TL1A mRNA水平(0.39±0.17)明顯高于對照組(0.31±0.11),差異有統計學意義(P=0.001).結論 病毒性心肌炎患者外週血TL1A錶達水平升高,TL1A可能參與瞭病毒性心肌炎的髮病過程.
목적 탐토종류배사인자배체상관분자1A(TL1A)재병독성심기염환자외주혈중적표체수평급림상의의.방법 분별채용매련면역흡부시험법화실시정량PCR법검측70례병독성심기염환자(병독성심기염조)급70례건강체검자(대조조)혈장TL1A수평화외주혈TL1A mRNA적표체수평.결과 병독성심기염조혈장TL1A수평[(1.37±0.41) μg/L]명현고우대조조[(0.85±0.22)μg/L],차이유통계학의의(P=0.000)；병독성심기염조외주혈TL1A mRNA수평(0.39±0.17)명현고우대조조(0.31±0.11),차이유통계학의의(P=0.001).결론 병독성심기염환자외주혈TL1A표체수평승고,TL1A가능삼여료병독성심기염적발병과정.
Objective To explore the expressive level and clinical significance of tumor necrosis factor ligands related molecule 1A (TL1A) in peripheral blood of patients with viral myocarditis.Methods In 70 patients with viral myocarditis (viral myocarditis group) and 70 normal controls (control group),the plasma level of TL1A was detected by enzyme linked immunosorbent assay and the mRNA level of TL1A was detected by real-time quantitative reverse transcription polymerase chain reaction.Results The plasma level of TL1A in viral myocarditis group was significantly higher than that in control group [(1.37 ± 0.41) μg/L vs.(0.85 ± 0.22) μg/L](P=0.000).The level of peripheral blood TL1A mRNA in viral myocarditis group was significantly higher than that in control group (0.39 ±0.17 vs.0.31 ±0.11,P =0.001).Conclusion The level of TL1A in patients with viral myocarditis is increased,and TL1A may participate in the occurrence of viral myocarditis.
